A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain

Inclusion Criteria:

• have a visual analog scale (VAS) pain value >40 and <95 at screening andprerandomization screening.

• have a history of daily pain for at least 12 weeks based on participant report ormedical history

• have a value of ≤30 on the pain catastrophizing scale

• have a body mass index <40 kilogram/square meter (kg/m²) (inclusive)

• are willing to maintain a consistent regimen of any ongoing nonpharmacologicpain-relieving therapies (for example, physical therapy) and will not start any newnonpharmacologic pain-relieving therapies during study participation.

• are willing to discontinue all medications taken for chronic pain conditions, exceptrescue medication for the duration of the study

Exclusion Criteria:

• have second- or third-degree atrioventricular (AV) heart block or AV dissociation orhistory of ventricular tachycardia

• have had a procedure within the past 6 months intended to produce permanent sensoryloss in the target area of interest (for example, ablation techniques)

• have surgery planned during the study for any reason, related or not to the diseasestate under evaluation.

• have, in the judgment of the investigator, an acute, serious, or unstable medicalcondition or a history or presence of any other medical illness that would precludestudy participation.

• have had cancer within 2 years of baseline, except for cutaneous basal cell orsquamous cell carcinoma resolved by excision.

• have fibromyalgia

• have substance use disorder as defined by the Diagnostic and Statistical Manual ofMental Disorders (5th edition; DSM-5; American Psychiatric Association)

• have any clinically important abnormality at screening, as determined byinvestigator, in physical or neurological examination, vital signs,electrocardiogram (ECG), or clinical laboratory test results that could bedetrimental to the participant or could compromise the study.

• have a positive human immunodeficiency virus (HIV) test result at screening

• have a history of alcohol, illicit drug, analgesic or narcotic use disorder within 2years prior to screening.