Safety and Efficacy of Topical Cream for Post-inflammatory Hyperpigmentation Skin Among Malaysians

Last updated: March 24, 2025
Sponsor: Ungku Shahrin Medical Aesthetic Research & Innovation (USMARI) Centre
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

Topical cream Z for PIH

Clinical Study ID

NCT05986123
UMRAMREC002-23
  • Ages 18-40
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

This study was conducted to determine safety and efficacy of topically applied cream containing combination of niacinamide, arbutin, Scutellaria Baicalensis Root Extract, Centella Asiatica Extract and Camellia Sinensis Leaf Extract for its skin brightening effect on post-inflammatory hyperpigmentation among the Malaysian population. The study duration is 20 weeks and the skin assessment will be carried out at baseline, week 4, week 8, week 12, week 16 and week 20.The main questions this study aims to answer are:

  1. To determine the efficacy of topical cream containing natural plant extracts, niacinamide, and arbutin for post-inflammatory hyperpigmentation among Malaysians.

  2. To investigate the safety of topical cream containing natural plant extracts, niacinamide, and arbutin for post-inflammatory hyperpigmentation among Malaysians.

  3. To assess the participants satisfaction of using topical cream containing natural plant extracts, niacinamide, and arbutin for post-inflammatory hyperpigmentation among Malaysians.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Malaysia citizen

  • Healthy adult, aged between 18 to 40 years old.

  • Participants who have post-inflammatory hyperpigmentation on skin

Exclusion

Exclusion Criteria:

  • Participants with skin disorders such as skin infection or skin inflammation.

  • Participants who have undergone any skin and cosmetic treatments such as dermalfillers, botox, laser, chemical peels within the last 3 months.

  • Participant who is taking isotretinoin for the past 6 or 12 months andimmunocompromised patients.

  • Pregnant, breastfeeding women or planned for pregnancy during the study period.

Study Design

Total Participants: 25
Treatment Group(s): 1
Primary Treatment: Topical cream Z for PIH
Phase:
Study Start date:
November 01, 2023
Estimated Completion Date:
November 30, 2025

Connect with a study center

  • Ungku Shahrin Medical Aesthetic Research & Innovation (USMARI) Centre

    Petaling Jaya, Selangor 47810
    Malaysia

    Active - Recruiting

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