GpCRC Pediatric Gastroparesis Registry 2

Inclusion Criteria:

• Provision of signed and dated informed consent form and assent, as age appropriate.

• Stated willingness to comply with all study procedures and availability for theduration of the study

• 8 to 25 years of age at the time of enrollment

• Symptoms of Gp of at least 12 weeks duration: constellation of some combination of:

nausea, vomiting, early satiety, postprandial fullness; symptoms sometimes may be accompanied by upper abdominal pain

• Have undergone a gastric emptying scintigraphic study of solids using 4-hour EggBeaters protocol (or equivalent generic liquid egg white meal) within the last 12months who fall into one of the two categories:

• Delayed gastric emptying-defined as an abnormal 2-hour (>60% retention) and/or 4-hour (>10% retention) result based on a 4-hour scintigraphic gastric emptying study

• Gastric emptying that is not delayed but who have symptoms of Gp (designated in thisstudy as GLS) or have previously participated in the Pediatric GastroparesisRegistry (PGpR) study

• An etiology of either diabetic or idiopathic Gp or GLS

Exclusion Criteria:

• Inability to comply with or complete the scintigraphic gastric emptying test (including allergy to eggs)

• Pregnancy

• Autism spectrum disorder, significant developmental delay, psychosis (because ofinability to complete questionnaires)

• Use of narcotic analgesics greater than three days per week.

• Presence of conditions associated with GI mucosal disease (e.g., inflammatory boweldisease, known eosinophilic gastroenteritis or eosinophilic esophagitis, gastriculcer, peptic ulcer, celiac disease)

• Presence of any other condition that could case delayed gastric emptying

• Gastrointestinal construction confirmed by upper endoscopy (EGD), uppergastrointestinal series (UGI), or abdominal CT

• Primary neurological conditions that can cause nausea and vomiting such as increasedintracranial pressure, space occupying or inflammatory/infectious legions

• Acute or chronic renal failure (abnormal creatinine for age) and /or on hemodialysisor peritoneal dialysis

• Acute liver failure

• Advanced liver disease (features of portal hypertension)

• Clinically significant congenital heart disease (i.e., vaginal injury during cardiacrepair)

• History of esophageal, gastric or bowel surgery.

• Metabolic disease including mitochondrial disease and inborn errors of metabolism

• Chronic lung disease (including cystic fibrosis)

• A serious chronic medical condition (e.g., inflammatory bowel disease)

• Use of medications that can affect motility during the gastric emptying study

• Any other condition, which in the option of the investigator, could explain thesymptoms or could interfere with study requirements.