Obstructive Sleep Apnea (OSA), Oral Frailty, Dysphagia, Continuous Positive Airway Pressure (CPAP)

Last updated: May 19, 2025
Sponsor: National Cheng-Kung University Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Heartburn

Sleep Apnea Syndromes

Treatment

CPAP

Clinical Study ID

NCT05977296
A-ER110-551
  • Ages > 50
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The purpose of this study is to evaluate the effects of the CPAP treatment on oral frailty and dysphagia among OSA patients.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age 50 years or older.

  • Medically diagnosed with obstructive sleep apnea (apnea and hypopnea index, AHI, ≥ 5events per hour).

  • Clear consciousness and able to communicate in Mandarin or Taiwanese.

Exclusion

Exclusion Criteria:

  • Central sleep apnea patients.

  • Patients with neurological or muscular disorders (such as stroke or Parkinson'sdisease).

  • Patients diagnosed with oral cancer currently undergoing oral treatment.

Study Design

Total Participants: 450
Treatment Group(s): 1
Primary Treatment: CPAP
Phase:
Study Start date:
April 14, 2022
Estimated Completion Date:
December 31, 2025

Study Description

The research will be divided into three stages. The first stage will investigate the incidence of OSA in patients over 50 years old using the National Health Insurance Research Database (NHIRD). The second stage will examine the relationships among OSA, oral frailty, and dysphagia through an observational case-control study with 225 OSA patients and 225 controls. The third stage will evaluate the effects of CPAP treatment on oral frailty and dysphagia among moderate-severe OSA persons through a prospective cohort study with repeat four times measurements.

Connect with a study center

  • National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University

    Tainan, 704
    Taiwan

    Active - Recruiting

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