Special Drug Use Surveillance of Entresto Tablets (Hypertension)

Inclusion Criteria:

1. Patients who have given written consent to participate in this study before thestart of treatment with Entresto

2. Patients who used Entresto for the first time for the indication of hypertension

Exclusion Criteria:

1. Patients who have received a formulation containing the same ingredient as Entresto (including investigational product or post-marketing clinical study drug)

2. The following patients for whom administration of Entresto is contraindicated in thepackage insert:

• Patients with a history of hypersensitivity to any of the ingredients ofEntresto

• Patients who are receiving angiotensin-converting enzyme inhibitors (alacepril,imidapril hydrochloride, enalapril maleate, captopril, quinapril hydrochloride,cilazapril hydrate, temocapril hydrochloride, delapril hydrochloride,trandolapril, benazepril hydrochloride, perindopril erbumine, and lisinoprilhydrate) or who discontinued these drugs within 36 hours.

• Patients with a history of angioedema (angioedema due to angiotensin IIreceptor antagonists or angiotensin converting enzyme inhibitors, hereditaryangioedema, acquired angioedema, idiopathic angioedema, etc.)

• Patients with diabetes mellitus who are receiving aliskiren fumarate

• Patients with severe hepatic impairment (Child-Pugh class C)

• Pregnant or possibly pregnant women

3. Patients with a history or complication of cardiac failure

4. Patients who have been hospitalized at the start of treatment with Entresto