MIND Diet and Cognitive Function in Adults With MCI

Last updated: August 3, 2023
Sponsor: Zhejiang University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Dementia

Mental Disability

Mild Cognitive Impairment

Treatment

MIND diet education

Routine follow-up and general advice

Clinical Study ID

NCT05975723
AARG-22-928604
  • Ages 60-80
  • All Genders

Study Summary

To examine the effects of a 1-year cluster-randomized controlled intervention of MIND diet on cognitive function among 240 participants with mild cognitive function (MCI) aged 50 years and above from 4 communities.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • At risk of cognitive decline: cognitive performance at the mean level or slightlylower than expected for age with no dementia (AD8>=3 and/or 5-min MoCA < 11)
  • Free of physical disabilities that preclude participation in the study
  • Willing to complete all study-related activities for 24 months
  • Willing to be randomized to either intervention group

Exclusion

Exclusion Criteria:

  • Allergic to more than one type of food (nuts, berries, olive oil, or fish)
  • Diagnosed of dementia, severe diabetes mellitus, cardiovascular disease, cancer,thyroid disease, kidney disease, or liver disease
  • Diagnosed of major depression or other neuropsychological diseases
  • Severe loss of vision, hearing or communicative ability
  • Substance abuse within 6 months or heavy alcohol consumption (> 2 drinks/day forwomen; > 3 drinks/day for men).

Study Design

Total Participants: 240
Treatment Group(s): 2
Primary Treatment: MIND diet education
Phase:
Study Start date:
July 26, 2023
Estimated Completion Date:
August 31, 2025

Study Description

The current study is a 1-year cluster-randomized controlled intervention trial designed to examine whether the a localized modified Mediterranean-Dietary Approaches to Stop Hypertension (DASH) dietary intervention for neurodegenerative delay (MIND) diet will improve cognitive function among 240 participants with MCI from 4 communities. The modified MIND diet recommends 11 brain healthy food groups (green leafy vegetables, dark red and yellow vegetables, other vegetables, nuts, berries, beans, whole grains, seafood, poultry, olive/tea-seed oil and green tea) and limits intake of 4 unhealthy food groups (red meat and products, animal oil, pastries and sweets, and fried/fast food). This study will randomly assign 240 MCI participants to two groups: A) MIND diet intervention group and B) control group, and estimate the cognitive and biological impacts of the 1-year intervention.

Connect with a study center

  • Zhejiang University School of Medicine

    Hangzhou, Zhejiang 310058
    China

    Active - Recruiting

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