A Study to Evaluate the Safety and Immunogenicity of mRNA-1975 and mRNA-1982 Against Lyme Disease in Participants 18 Through 70 Years of Age

Inclusion Criteria:

• Body mass index of 18 to 39 kilograms/square meter (inclusive) at the ScreeningVisit.

• Participants of nonchildbearing potential may be enrolled in the study.

• For female participants of childbearing potential: negative pregnancy test, adequatecontraception or has abstained from all activities that could result in pregnancyduring the study intervention period, and agreement to continue adequatecontraception or abstinence through 3 months following last study injection.

Exclusion Criteria:

• Have chronic illness related to Lyme disease or an active symptomatic Lyme diseaseinfection as suspected or diagnosed by a physician.

• Received treatment for Lyme disease within the prior 3 months.

• Had previous vaccination against Lyme disease or participated in the past in anyvaccine study for Lyme disease.

• Had a tick bite within 4 weeks prior to the study injection visit.

• Dermatologic conditions that could affect local solicited AR assessments (forexample, tattoos; psoriasis patches affecting skin over the deltoid areas).

• Received systemic immunosuppressants for >14 days in total within 180 days prior tothe Screening Visit (for corticosteroids, ≥10 milligrams/day of prednisone orequivalent) or is anticipating the need for systemic immunosuppressive treatment atany time during participation in the study.

• History of myocarditis, pericarditis, or myopericarditis regardless of the timing ofpast medical history.

• History of anaphylaxis, urticaria, or other significant adverse reaction requiringmedical intervention after receipt of a vaccine or intervention that includes one ormore of the same components contained in the study injection.

• Has received systemic immunoglobulins, long-acting biological therapies that affectimmune responses (for example, infliximab) or blood products within 90 days prior tothe Screening Visit or plans to receive them during the study.

Note: Other inclusion and exclusion criteria may apply.