Stratified Therapy on Pediatric AAGN

Inclusion Criteria:

• 1. Newly diagnosed AAGN patients with onset age of 5-17 years, complete renal biopsyand regular follow-up in the hospital; 2) All enrolled children met the followinginclusion criteria: ANCA classification criteria: Patients who meet the 2007 EuropeanMedicines Agency (EMA) classification algorithm or the 2012 CHCC definition. Clinicalclassification includes: micropolyvasculitis (MPA), granulomatous polyvasculitis (GPA)and eosinophilic granulomatous polyvasculitis (EGPA); AAGN diagnostic criteria: ANCA vasculitis combined with any of the following:

1. Hematuria: gross hematuria or microscopic hematuria: 3 times microscopic hematuriawithin 1 week: red blood cells &gt in urine routine; 3 / high magnification field (HP)or > 17 /ul (higher than normal value, can be adjusted according to the standard ofthe laboratory of each center);
2. proteinuria: meet any of the following: ① 3 times in 1 week urine routine proteinpositive; 2) 24h urinary protein quantification > 150 mg or urinaryprotein/creatinine (mg/mg)> 0.2; 3 urinary microalbumin higher than normal for 3times in 1 week;
3. Renal insufficiency: increased serum creatinine > 10% base or decreased creatinineclearance > 25%.

Exclusion Criteria:

• 1. Patients who relied on dialysis for more than 1 month at the time of diagnosis, or theproportion of glomerular sclerosis ≥75% at the time of renal biopsy; 2) Patients withsevere infection (such as diffuse peritonitis, severe pneumonia, cellulitis, activeEpstein-Barr virus infection, active cytomegalovirus infection, hepatitis B virusinfection, tuberculosis infection, fungal infection, etc.) and tumor.

3. Patients with other primary or secondary kidney diseases (such as IgA nephropathy,membranous nephropathy, anti-glomerular basement membrane nephritis, polycystic kidneydisease, renal dysplasia, urinary tract malformation, etc.); 4) Parents or children refusedto join the group.