Complex And Simple Appendicitis: REstrictive or Liberal Post-operative Antibiotic eXposure - UCSF

Last updated: May 5, 2025
Sponsor: University of California, San Francisco
Overall Status: Active - Recruiting

Phase

4

Condition

Appendicitis

Treatment

Multiple standard of care antibiotics for appendicitis, at physicians' discretion

Clinical Study ID

NCT05966454
21-35457
  • Ages > 18
  • All Genders

Study Summary

The purpose of this study is to demonstrate the safety, efficacy, and feasibility of short-course post-operative antibiotic treatment for simple and complicated appendicitis

Eligibility Criteria

Inclusion

Inclusion Criteria:

Age ≥ 18 years

  • Age ≥ 18 years

  • Planned appendectomy (laparoscopic or open)

  • Working telephone number or reliable method to contact patient after hospitaldischarge

Exclusion

Exclusion Criteria:

  • Unable to consent

  • Pregnant Women

  • Prisoners

  • Immunocompromised as determined by clinical team, or patients actively receivingsteroids, chemotherapy, or immunosuppressing medications (for example tacrolimus),or patients with active hematologic malignancy affecting the immune system,leukopenia, or end-stage AIDS

  • Heart failure

  • Allergy to bupivacaine

  • Unlikely to comply with treatment or follow-up

  • Inpatient consultation for appendicitis

  • Clinically suspected of sepsis based on Sepsis-3 definition

  • Current use of antibiotics for other indications

  • Type 1 Diabetes or uncontrolled hyperglycemia

  • Surgeon preference

  • Patient preference

  • Research team unavailable

Study Design

Total Participants: 145
Treatment Group(s): 1
Primary Treatment: Multiple standard of care antibiotics for appendicitis, at physicians' discretion
Phase: 4
Study Start date:
June 06, 2023
Estimated Completion Date:
June 30, 2026

Study Description

This is a single center, randomized controlled trial to determine if decreasing the amount of antibiotics after appendicitis surgery can decrease the risk of adverse effects associated with antibiotics while at the same time ensuring participant safety.

Connect with a study center

  • Zuckerberg San Francisco General Hospital

    San Francisco, California 94110
    United States

    Active - Recruiting

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