rTMS-tACS Stimulation on Improving Cognitive Function in Bipolar Disorder

Last updated: July 20, 2023
Sponsor: First Affiliated Hospital of Zhejiang University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Bipolar Disorder

Mood Disorders

Treatment

Repetitive Transcranial magnetic stimulation and transcranial alternating current stimulation

Clinical Study ID

NCT05964777
IIT20230058C-R1
  • Ages 14-45
  • All Genders

Study Summary

Based on the individualized positioning technology of diffusion tensor imaging (DTI), the purpose of this study is to explore a new stimulation target and protocol for the treatment of bipolar disorder in remission through the repetitive transcranial magnetic stimulation(rTMS) and transcranial alternating current stimulation（tACS）under neuronavigation，verify whether there is abnormal functional connectivity and structural connections between the dorsolateral prefrontal cortex (dlpfc) and the dorsal anterior cingulate gyrus (dacc) related to cognitive impairment in bipolar disorder in remission, which will contribute to further understand the relevant neural pathway and mechanism.

Eligibility Criteria

Inclusion

Inclusion Criteria:

    1. Age 14-45 years old, regardless of gender] 2.Meet DSM-V diagnostic criteria forbipolar depressive in remission 3.Young Mania Rating Scale (YMRS) ≤ 6 points; 4.Hamilton Depression Scale(HAMD-17)≤7 points; 5.Cognitive deficit questionnairePDQ≥17 points; 6.Han nationality, right-handed; 7.More than 9 years of education.

Exclusion

Exclusion Criteria:

  1. History of severe somatic or brain organic diseases and craniocerebral trauma;
  2. Abnormal brain structure or any MRI contraindications were found by magnetic resonanceexamination;
  3. Those who do not cooperate or cannot effectively complete the experiment;
  4. Drug, alcohol or other psychoactive substance abusers;
  5. Pregnant, lactating or planned pregnancy;
  6. ECT or rTMS or tACS treatment was performed within six months.

Study Design

Total Participants: 54
Treatment Group(s): 1
Primary Treatment: Repetitive Transcranial magnetic stimulation and transcranial alternating current stimulation
Phase:
Study Start date:
July 01, 2023
Estimated Completion Date:
April 04, 2024

Connect with a study center

  • Department of Psychiatry, First Affiliated Hospital of Zhejiang University

    Hangzhou, Zhejiang 310000
    China

    Active - Recruiting

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