Phase
Condition
Anxiety Disorders
Panic Disorders
Mood Disorders
Treatment
Placebo
Heat-treated PS23
Clinical Study ID
Ages 20-70 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Age 20~70 years old
Patients perceived that they had anxiety-related complaints, or with any type ofanxiety disorders of adjustment disorders referred from the Departments ofPsychiatry, Neurology, Internal Medicine, and Family Medicine in Mackay MemorialHospital.
Adult GAD-7 ≥ 8 points (to screen for generalized anxiety disorder) or a DSM-5diagnosis of generalized anxiety disorder (F41.1) or unspecified anxiety disorder (F41.9)
Those who are currently under the treatment of selective serotonin reuptakeinhibitors (SSRI) will only be included if their SSRI treatment has been stable orhas not been changed for 4 weeks.
Exclusion
Exclusion Criteria:
Have taken antibiotics or are receiving antibiotic treatment within one month.
Have used probiotic products in powder, capsule or tablet form within two weeks (excluding yogurt, Yakult and other related foods).
Patients who have undergone hepatobiliary gastrointestinal surgery (except forcolorectal polypectomy and appendectomy).
Past or current patients with inflammatory bowel disease.
Those with a history of cancer.
Those who are allergic to lactic acid bacteria products.
Patients with severe depression (Patient Health Questionnaire-9 (PHQ-9) ≧ 20points), or possible neurocognitive impairments (Mini-Mental States Examination (MMSE)<20), or those that had suicidal ideation noted on item 9 from PHQ-9.
Patients with chronic psychiatric diseases who are currently taking drugs to treatacute diseases, organic brain diseases, or newly diagnosed or changed drugs withinone month.
Those who are receiving parenteral nutrition.
Those who are evaluated by the principal investigator to be unsuitable toparticipate in the research.
Study Design
Study Description
Connect with a study center
Mackay Memorial Hospital
Taipei, 10448
TaiwanActive - Recruiting
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