IS-001 Injection in Patients Undergoing Robotic-Assisted Gynecological Surgery

Inclusion Criteria:

1. Female subject is between the ages of 16 and 75, inclusive at time of consent.

2. Subject is scheduled to undergo robotic-assisted gynecological procedure using a daVinci® Surgical System with Firefly® Fluorescence Imaging.

3. Subject and/or subject's parent/guardian is willing and able to provide informedconsent and/or assent as applicable.

Exclusion Criteria:

1. Subject is pregnant or nursing.

2. Subject has known active hepatitis B virus (HBV) or hepatitis C virus (HCV)infection.

3. Subject is already enrolled in another investigational drug or device studyreceiving therapeutic agents within the past 6 months

4. Subject has any other condition or personal circumstance that, in the judgment ofthe Investigator, might interfere with the collection of complete quality data orrepresents an unacceptable safety profile

5. Subject has a known or suspected hypersensitivity to indocyanine green (ICG)

6. Subject has any of the following screening laboratory values:

7. eGFR < 60 mL/min/1.73 m^2

8. Aspartate aminotransferase (AST) or serum glutamic oxaloacetic transaminase (SGOT) ≥ 2.5 × ULN

9. Alanine aminotransferase (ALT) or serum glutamic pyruvic transaminase (SGPT) ≥ 2.5 × ULN.

10. Planned use of CYTALUX™ (pafolacianine) for surgery