The TRIple Elimination Model Of Mother-to-child Transmission Program (TRI-MOM)

Last updated: June 17, 2024
Sponsor: Institut de Recherche pour le Developpement
Overall Status: Active - Recruiting

Phase

N/A

Condition

Sexually Transmitted Diseases (Stds)

Rash

Hepatitis B

Treatment

TRI-MOM intervention

Clinical Study ID

NCT05951751
IRD_2023_SESSTIM_TRI-MOM
  • Female
  • Accepts Healthy Volunteers

Study Summary

The TRI-MOM program aims to implement and evaluate a simplified (based on inexpensive rapid diagnostic tests), integrated (in governmental health facilities) and coordinated (between health care workers) strategy for the triple elimination of HIV, syphilis and HBV mother-to-child transmission (MTCT) in nine maternal and child health services, 5 in Burkina Faso and 5 in The Gambia.

The TRI-MOM program has two components:

  1. an "intervention" component consisting of a pilot study to reinforce the antenatal screening and prevention of MTCT (PMTCT) capacities for the 3 targeted infections through the implementation of a simplified, integrated and coordinated strategy of triple elimination of MTCT.

  2. an "evaluation" component which will assess the impact of the TRI-MOM strategy on PMTCT services, reduction of HBV MTCT and women empowerment.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Women attending a postnatal visit in one of the selected maternities (no maternalage limit)

Exclusion

Exclusion Criteria:

  • Refusal to participate in the study

  • Unable to provide consent

Study Design

Total Participants: 2800
Treatment Group(s): 1
Primary Treatment: TRI-MOM intervention
Phase:
Study Start date:
March 18, 2024
Estimated Completion Date:
May 31, 2025

Study Description

The TRI-MOM (TRIple elimination Model Of Mother-to-child transmission of HIV/Syphilis and HBV in Burkina Faso and The Gambia) program aims to implement and evaluate a simplified (based on inexpensive rapid diagnostic tests), integrated (in governmental health facilities) and coordinated (between health care workers) strategy for the triple elimination of HIV, syphilis and HBV MTCT in nine maternal and child health services, 5 in Burkina Faso and 5 in The Gambia. In The Gambia, the program will be conducted in collaboration with the national HIV, sexually transmitted infections (STI) and hepatitis programmes.

The TRI-MOM program has two components:

  1. an "intervention" component consisting of a pilot study to reinforce the antenatal screening and PMTCT capacities for the 3 targeted infections through the implementation of a simplified, integrated and coordinated strategy of triple elimination of MTCT. This pilot study will be conducted in 9 selected maternities.

  2. an "evaluation" component which will assess the impact of the TRI-MOM strategy on PMTCT services, reduction of HBV MTCT and women empowerment.

Intervention component :

The TRI-MOM strategy includes 4 main activities:

  1. Training of healthcare professionals in charge of maternal health (nurses, midwives and doctors in charge of maternal health services)

  2. Triple screening of HIV, Syphilis and HBV by rapid diagnostic tests

  3. Assessment and treatment of women positive for any of the 3 targeted infections

  4. Raising awareness on MTCT among pregnant women visiting antenatal services and empowering women infected with at least one of the three infections

Evaluation component :

The TRI-MOM program will include three studies :

  1. A quantitative and qualitative cross-sectional study before and after the implementation of the strategy.

  2. A cohort study of pregnant women positive for any of the three infections.

  3. Cost and cost-effectiveness analysis.

Connect with a study center

  • Centre Muraz/INSP

    Bobo-Dioulasso,
    Burkina Faso

    Site Not Available

  • MRC The Gambia at LSHTM

    Fajara,
    Gambia

    Active - Recruiting

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