Effect of Blood Flow Restriction Training to Muscle Strength, Dynamic Stability, and ACL Injury Prevention

Last updated: June 27, 2025
Sponsor: Udayana University
Overall Status: Completed

Phase

N/A

Condition

Healthy Volunteers

Treatment

Low-load Blood Flow Restriction training

Sham Low-load Blood Flow Restriction training

High-load Eccentric training

Clinical Study ID

NCT05951036
1575/UN14.2.2.VII.14/LT/2023
  • Ages 15-35
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The goal of this randomized clinical trial study is to compare low-load blood flow restriction (LL-BFRt), sham LL-BFRt, and high-load eccentric training (HL-Et) in healthy level 1 sportsman. The main questions it aims to answer are:

  1. Does LL-BFR improve muscle strength better than sham LL-BFRt and HL-Et?

  2. Does LL-BFR improve dynamic stability better than sham LL-BFRt and HL-Et?

  3. Does LL-BFR prevent ACL injury better than sham LL-BFRt and HL-Et?

Participants will be randomized into three intervention groups: LL-BFRt, sham LL-BFRt, and HL-Et. Participants will be asked to do:

  • In LL-BFRt, participants will be asked to do LL eccentric training (including double leg squats, split squats, deadlifts, and monster walks) with a 30% of repetition maximum (RM) and 70% of arterial occlusion pressure (AOP).

  • In sham LL-BFRt, participants will be asked to do LL eccentric training with a 30% of repetition maximum (RM) and 10% of arterial occlusion pressure (AOP).

  • In HL-Et, participants will be asked to do LL eccentric training with a 70% of repetition maximum (RM).

Researchers will compare LL-BFRt, sham LL-BFRt, and HL-Et to see if muscle strength, dynamic stability, and ACL injury prevention improve after the interventions and follow-up.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Being 15-35 years old

  • Perform sports level 1 (soccer, basket ball, futsal, combat martial art) at leasttwice per week.

  • Never had an history of ACL injury

  • Never had an history of sprain or strain grade III

  • Agree to participate until the end of this study period and sign the inform consent

Exclusion

Exclusion Criteria:

  • Having hypertension, blood circulation disease, anemia, obesity, diabetes, kidneyfailure, vena thromboembolic, cancer, and tumor.

  • Disabilities or disabled people.

Study Design

Total Participants: 60
Treatment Group(s): 3
Primary Treatment: Low-load Blood Flow Restriction training
Phase:
Study Start date:
July 17, 2023
Estimated Completion Date:
November 30, 2024

Study Description

Participants will be asked to do five sets of ten repetitions of each eccentric training, one-minute rest interval for each eccentric training and two mins rest interval between each set.

Connect with a study center

  • Physical therapy laboratory, College of Medicine, Universitas Udayana and ROM Physiotherapy Private Clinic Denpasar

    Denpasar, Bali 80232
    Indonesia

    Site Not Available

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