Working Memory and Physical Exercise Training in Patients With Mild Cognitive Impairment

Inclusion Criteria:

• Adult men and women of all races and ethnicities who are 50-80 years of age will beeligible.

• Only sedentary adults will be eligible (engaging in structured activity for exercise <3x/week) for Progressive aerobic exercise or Combined training

• Ability to use, and accessibility to, an iPad or computer is required for theAdaptive cognitive training and Combined training.

• Fluent in English.

• The diagnosis of MCI will first be confirmed at the screening evaluation using theclinical dementia rating (CDR) scale and the Montreal Cognitive Assessment (MoCA).We will also evaluate their ADL using instrumental activities of daily living (IADL)to ensure they have preserved independence in functional abilities despite thecognitive deficits. The primary caregivers will be interviewed (either in person orby phone) for the participants' IADL to corroborate the independent functionalstatus.

Exclusion Criteria:

• Does not have access to a computer or internet to perform the Cogmed® training ANDis unwilling to come to the lab for the training.

• Unable to undergo an MRI investigation based on claustrophobia or metal foreignbodies.

• Symptomatic heart disease, Coronary artery disease, congestive heart failure,uncontrolled hypertension, uncontrolled diabetes (HbA1c>10%), significantcardiovascular disorders (on EKG and graded exercise test) that would prevent theparticipant from the exercise training; neurologic, musculoskeletal, or othercondition that limits the subject's ability to complete study physical assessments.

• Estimated verbal Intelligence Quotient (IQ) below 70 (based on the Wechsler Test ofAdult Reading) which would invalidate the informed consent process for the study.

• Self-reported moderate to severe substance use disorder(s) (e.g., self-reportedintake >3 oz liquor, or three 4 oz glasses of wine, or three 12 oz cans of beer perday or illicit drug use).

• Severe chronic or acute medical or other (non-MCI) neuropsychiatric conditions thatmight confound the cognitive or brain imaging measures (e.g., liver function tests >2.5 normal range or evidence for renal failure).

• Body mass index >40 kg/m2.