A First in Human Study to Evaluate Safety, Tolerability, Pharmacology of HS-10390 in Healthy Subjects

Inclusion Criteria:

• Healthy male or female subjects between the ages of 18-45 years

• Have no reproductive potential; or agree to use a highly effective methodofcontraception, and refrain from donating sperm or eggs during the study period andforat least 6 months after last dosing

• Have signed the informed consent form approved by the IRB

Exclusion Criteria:

• History or evidence of clinically significant cardiovascular, pulmonary,endocrine,gastrointestinal, psychiatric, neurologic, hematological or metabolicdiseases, especiallythose conditions that interfere with absorption, metabolismand/or excretion of the studydrug, determined by the investigator

• Have a clinically significant infection currently or within past 30 days, or have ahistory ofactive tuberculosis; or have positive screening test for infectiousdisease, includingtuberculosis, viral hepatitis, AIDS and syphilis

• Have a history of or current allergic disease

• Have a history of drug or alcohol abuse or currently positive test result(s) foralcohol ordrugs of abuse

• Smokers smoked ≥5 cigarettes per day within past 3 months or have a positive testresultfor nicotine

• Clinically significant abnormal physical examination, vital signs, clinicallaboratory values,ECGs or imaging tests

• Pregnant or breastfeeding female subjects