IC Plus Low-dose Radiation Plus Cadonilimab in LANPC

Inclusion Criteria:

• Newly histologic diagnosis of nasopharyngeal non-keratinizing carcinoma (WHOII/III);

• All genders, range from 18-70 years old;

• ECOG score 0-1;

• Clinical stage T4N1M0 and T1-4N2-3M0 (AJCC/UICC 8th);

• Not received radiotherapy, chemotherapy and other anti-tumor treatment (includingimmunotherapy);

• No contraindications to chemotherapy, radiotherapy or immunotherapy;

• Adequate organ function: white blood cell count ≥ 4×109/L, neutrophile granulocytecount ≥ 1.5×109/L, hemoglobin ≥ 9g/L, platelet count ≥ 100×109/L; alanineaminotransferase or aspartate aminotransferase < 2.5×upper limit of normal; bloodurea nitrogen or creatinine ≤ 1.5×upper limit of normal or endogenous creatinineclearance ≥ 60ml/min (Cockcroft-Gault formula);

• Sign the consent form.

Exclusion Criteria:

• Distant metastases;

• Keratinized squamous cell carcinoma or basal cell like squamous cell carcinoma;

• Have or are suffering from other malignant tumors;

• Participating in other clinical trials;

• Pregnancy or lactation;

• Have uncontrolled cardiovascular disease;

• Severe complication, eg, uncontrolled hypertension;

• Mental disorder;

• Drug or alcohol addition;

• Do not have full capacity for civil acts.