Comparison Between HA330 Hemoperfusion Filter Hemodialysis and Conventional High-Flux Hemodialysis Filter

Last updated: May 1, 2025
Sponsor: Indonesia University
Overall Status: Completed

Phase

N/A

Condition

Focal Segmental Glomerulosclerosis

Kidney Disease

Kidney Failure (Pediatric)

Treatment

Conventional Hemodialysis

Ha-330 Hemoperfusion Filter Hemodialysis

Clinical Study ID

NCT05941624
IndonesiaUAnes043
  • Ages 18-65
  • All Genders

Study Summary

The purpose of this study is to compare the effectiveness between conventional hemodialysis and hemodialysis using hemoperfusion adsorbents in renal dysfunction caused by sepsis

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients age 18 - 65 years old

  • Patients diagnosed with sepsis with acute kidney injury whose indicated forhemodialysis. Including fluid overload, life-threatening metabolic acidosis,hypercalcemia, pulmonary edema, and uremic

Exclusion

Exclusion Criteria:

  • Patients with hemodynamic instability who need norepinephrine more than 0.5microgram/kg/minute

  • Patients denied to be included in the study

Study Design

Total Participants: 33
Treatment Group(s): 2
Primary Treatment: Conventional Hemodialysis
Phase:
Study Start date:
June 16, 2023
Estimated Completion Date:
March 31, 2024

Study Description

This study is an open randomized clinical trial. Data were taken prospectively until the number of samples was fulfilled for analysis. Due to the intervention provided, this study was not blinded. Subjects were divided into 2 groups (group undergoing conventional hemodialysis and group undergoing HA330 hemoperfusion). Both groups underwent therapy for 4 hours, 3 times a week, with two days apart between dialysis. Inflammatory mediator levels were assessed 4 times, before and after each intervention. All subjects were given standard therapy as indicated such as antibiotics, oxygen supplementation, administration of vasopressors, nutrition, and other therapies as indicated.

Connect with a study center

  • Cipto Mangunkusumo Hospital

    Jakarta Pusat, DKI Jakarta 10430
    Indonesia

    Site Not Available

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