Registry of X-linked Adrenoleukodystrophy

Inclusion Criteria: X-ALD group：

• Meet the diagnostic criteria of X-ALD and supported by the results of genetic and verylong chain fatty acid (VLCFA) test;
• Age: 6 - 70 years old;
• Able to communicate normally, and complete the test of scale as instructed (confirmedby the field test of scale);
• Sign the informed consent. Carrier-control group: Healthy people who have no significant difference in age, sex and education comparing withthe X-ALD group, volunteer to participate in this study, could complete the test of scaleas instructed, and meet the following criteria:
• Eligible for asymptomatic carriers in genetic tests (preference of patient's motherand close relatives);
• Age: 6 - 70 years old, able to complete the test of scale as instructed (confirmed bythe field test of scale);
• No history of psychiatric diseases.

Exclusion Criteria:

• Other hereditary diseases;
• Other severe central nervous diseases;
• History of surgery of brain or eye;
• Psychiatric and psychological diseases, such as anxiety and depression;
• Metal foreign body or prosthesis in the human body (such as pacemaker and insulinpump), claustrophobia, and other MRI contraindications;
• History of surgery associated with gastrointestinal tract;
• No informed consent;
• Unable to tolerate MRI or eye related tests.