Analysis of Clinical Features of Chronic Liver Disease Complicated With Hepatopulmonary Syndrome

Last updated: July 3, 2023
Sponsor: Sun Jie
Overall Status: Active - Recruiting

Phase

N/A

Condition

Primary Biliary Cholangitis

Treatment

Proteomic sequencing

Clinical Study ID

NCT05932927
2022-096
  • Ages 18-100
  • All Genders

Study Summary

Hepatopulmonary syndrome (HPS) has unknown pathogenesis, limited treatment and poor prognosis. The onset of HPS is insidious and easy to be ignored. Many liver diseases such as "cirrhosis and related complications" are the core characteristics of Beijing You 'an Hospital, but the clinical characteristics of HPS patients in the center are still unclear. The investigators plan to make the diagnosis of HPS among chronic liver disease patients in the hospital according to the diagnostic criteria of HPS proposed in the Practice Guidelines of the International Society of Liver Transplantation in 2016, collect clinical data of HPS participants, evaluate the severity, analyze and summarize clinical characteristics, and conduct management and follow-up. At the same time, The investigators collect blood samples for proteomics tests. In order to improve the diagnosis and treatment level of HPS.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • chronic hepatitis Agreed to venous blood collection

Exclusion

Exclusion Criteria:

  • pneumonia, pulmonary vascular disease, interstitial pulmonary disease, COPD, bronchialasthma, lung cancer and other primary pulmonary diseases, acute upper gastrointestinalbleeding.

Study Design

Total Participants: 500
Treatment Group(s): 1
Primary Treatment: Proteomic sequencing
Phase:
Study Start date:
April 01, 2023
Estimated Completion Date:
June 01, 2024

Study Description

At present, the mechanism of hepatopulmonary syndrome is not clear. The researchers plan to use the extracted plasma for detection, protein extraction and quality control, and then proteolytic hydrolysis, computer detection, and bioinformatics analysis.

Connect with a study center

  • No.8, Xitoutiao, Youan Men Wai, Fengtai District

    Beijing, 100038
    China

    Active - Recruiting

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