Injured Submucosal Arteries After CSP for 10-19 mm Nonpedunculated Colorectal Polyps.

Last updated: May 14, 2025
Sponsor: Showa Inan General Hospital
Overall Status: Completed

Phase

N/A

Condition

Colon Polyps

Polyps

Treatment

Experimental CS-EMR

Active Comparator HS-EMR

Experimental CSP

Clinical Study ID

NCT05930041
CSP/HSEMR
  • Ages 18-80
  • All Genders

Study Summary

Cold polypectomy has the advantages of simple operation, less time-consuming and fewer complications. Guidelines have recommended cold snare polypectomy (CSP) to resect small polyps sized <9 mm. CSP was designed to improve the complete resection rate and reduce adverse events. Investigators hypothesize that CSP is better than conventional hot snare endoscopic mucosal resection (HS-EMR) in the presence of injured submucosal arteries detected in the submucosal layer for 10-19 mm nonpedunculated colorectal polyps, resulting in lower delayed bleeding after CSP of 10-19 mm nonpedunculated colorectal polyps.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • at least one polyp sized 10-19 mm (Paris classification Is or IIa) revealed byendoscopic examination.

Exclusion

Exclusion Criteria:

  1. American Society of Anesthesiologists status class 3 or above

  2. poor bowel preparation (Boston Bowel Preparation Scale <6 points)

  3. endoscopic features indicating submucous infiltration or malignancy

  4. oral anticoagulants,or antiplatelet agents, or known blood coagulation disorders, orbleeding tendency

  5. a history of colorectal resection

  6. emergent colonoscopy (haemodynamic instability and/or continued activegastrointestinal bleeding and/or requiring intensive care patients)

  7. inflammatory bowel disease, familial polyposis and colorectal cancer

  8. pregnancy or lactation

  9. severe cardiopulmonary dysfunction, cirrhosis, chronic kidney disease, othermalignant tumours or severe infectious diseases.

Study Design

Total Participants: 124
Treatment Group(s): 3
Primary Treatment: Experimental CS-EMR
Phase:
Study Start date:
January 01, 2023
Estimated Completion Date:
December 31, 2024

Study Description

Cold polypectomy has the advantages of simple operation, less time-consuming and fewer complications. Guidelines have recommended cold snare polypectomy (CSP) to resect small polyps sized <9 mm. CSP was designed to improve the complete resection rate and reduce adverse events. Investigators hypothesize that CSP is better than conventional hot snare endoscopic mucosal resection (HS-EMR) in the presence of injured submucosal arteries detected in the submucosal layer for 10-19 mm nonpedunculated colorectal polyps, resulting in lower delayed bleeding after CS-EMR of 10-19 mm nonpedunculated colorectal polyps. The primary outcome measure was the presence of injured submucosal arteries detected in the submucosal layer. The secondary outcomes included immediate bleeding and the frequency of delayed bleeding requiring endoscopic treatment within 2 weeks after polypectomy. Immediate bleeding was defined as spurting or oozing which continued for more than 30 seconds.

Connect with a study center

  • Showa Inan General Hospital

    Komagane, Nagano 399-4117
    Japan

    Site Not Available

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