A Study of Retatrutide (LY3437943) in Participants With Type 2 Diabetes Mellitus Who Have Obesity or Overweight

Inclusion Criteria:

• Have a body mass index (BMI) greater than or equal to 27.0 kilogram/square meter (kg/m ²)

• Have Type 2 Diabetes (T2D)

• Are on stable treatment for T2D for at least 90 days

• Have a history of at least one unsuccessful dietary effort to lose body weight.

GSA2 Inclusion Criteria

• Previously diagnosed with OSA

• Have AHI ≥15 on polysomnography at screening (definition of moderate-to-severe OSA)

• For participants not on positive airway pressure (PAP) therapy: unable or unwillingto use PAP therapy and have not used PAP for at least 4 weeks prior to screening.

• If on PAP therapy, have been on PAP therapy for at least 3 consecutive months priorto screening, and willing to temporarily stop using PAP therapy for approximately 7days prior to each of the sleep study (PSG) visits.

Exclusion Criteria:

• Have a self-reported or documented change in body weight >5 kg (11 pounds) within 90days.

• Have taken weight loss drugs, including over-the-counter medications, within 90 daysprior to screening.

• Have a prior or planned surgical treatment for obesity.

• Have Type 1 diabetes

• Have a family or personal history of medullary thyroid carcinoma (MTC) or multipleendocrine neoplasia syndrome type 2 (MEN-2)

• Have had pancreatitis

GSA2 Exclusion Criteria

• Use stimulants (for example, modafinil, armodafinil, solriamfetol, pitolisant,amphetamine) less than 3 months prior to screening.

• Use hypnotics, mirtazapine, opioids, trazodone, and zonisamide less than 3 monthsprior to screening.

• Use a dental appliance or other device to treat OSA other than PAP therapy.