Alzheimer's Disease and Related Dementias (ADRD) Prevalence in American Samoa

Last updated: June 26, 2023
Sponsor: American Samoa Community Cancer Coalition
Overall Status: Active - Recruiting

Phase

N/A

Condition

Dementia

Treatment

N/A

Clinical Study ID

NCT05924529
ASCCC0191792
  • Ages > 50
  • All Genders

Study Summary

The goal of this study is to learn about ADRD prevalence within the Samoan population. Participants will be administered a series of cognitive assessments to determine cognitive status and a population-based prevalence of Mild Cognitive Impairment (MCI) and ADRD. Blood samples will also be collected from the participants for genetic and plasma biomarker analysis.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age 50 or older
  • Community dwelling
  • Speaks English or Samoan
  • Willing to contribute a biomarker specimen

Exclusion

Exclusion Criteria:

  • Residing in Assistant Living or Skilled Nursing Facility
  • Axis 1 Psychiatric diagnosis (e.g., Schizophrenia, Bipolar)
  • Unstable medical condition (i.e., metastatic cancer) that could preclude completion ofstudy visit

Study Design

Total Participants: 1098
Study Start date:
September 30, 2022
Estimated Completion Date:
September 30, 2025

Study Description

This study aims to do the following:

Test ADRD knowledge, health literacy, research readiness and determine ADRD resilience and vulnerability factors, and cognitive status in a probability sample of 981 Samoans age 50+ using culturally adapted instruments in our probability sample.

Conduct Gold Standard evaluations in our probability sample using the Uniform Data Set (UDSv3.0) from the National Institute on Aging (NIA) Alzheimer's Disease Research Center program to determine a population-based prevalence of MCI and ADRD for harmonization, data sharing, and comparison to other groups, and,

Cross-validate Gold Standard dementia evaluations with genetic (i.e., ApoE) and plasma Amyloid-Tau-Neuronal Injury/Neurodegeneration (ATN) framework biomarkers in our probability sample and compare to information available for other racial/ethnic groups.

Connect with a study center

  • Malaloa GHC Reid Building

    Pago Pago, 96799
    American Samoa

    Active - Recruiting

  • Sa'o Fetalai Building

    Pago Pago, 96799
    American Samoa

    Active - Recruiting

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