Safety of Low PEEP Maneuvers During ARDS Management

Last updated: July 9, 2024
Sponsor: Centre Hospitalier Universitaire, Amiens
Overall Status: Active - Recruiting

Phase

N/A

Condition

Lung Injury

Acute Respiratory Distress Syndrome (Ards)

Respiratory Failure

Treatment

N/A

Clinical Study ID

NCT05922969
PI2021_843_0165
  • Ages > 18
  • All Genders

Study Summary

Acute Respiratory distress syndrome (ARDS) is a severe condition in which protective ventilation is a critical point in its management. Positive end expiratory pressure (PEEP) setting can be challenging for clinicians and high PEEP has been associated with better outcome in moderate and severe ARDS. Recently, recruitment to inflation ratio and airway closure have been investigated in order to help PEEP adjustment. However, ventilatory maneuvers are performed with a low level of PEEP and therefore expose to derecruitment and oxygen desaturation. So far, the risk of oxygen desaturation has not been investigated and risk factors are unknown.

The aim of this study is to evaluate the prevalence of oxygen desaturation during ventilatory maneuvers at low level of PEEP in patients with moderate or severe ARDS

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • age : > 18 yo

  • inclusion criteria: ARDS, Mechanical ventilation, low PEEP maneuvers

Exclusion

Exclusion Criteria:

  • refusal to participate

Study Design

Total Participants: 50
Study Start date:
May 28, 2022
Estimated Completion Date:
November 30, 2024

Connect with a study center

  • CHU Amiens

    Amiens, 80480
    France

    Active - Recruiting

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