Fasting Mimicking Diet (FMD) in Conjunction With Chemotherapy in Advanced Ovarian Cancer

Inclusion Criteria:

1. Age ≥ 18 years
2. All patients with advanced ovarian, fallopian tube and primary peritoneal carcinomasdeemed appropriate candidates for neoadjuvant chemotherapy and patients withrecurrent, platinum-sensitive disease (as defined by an interval of at least 6 monthsfollowing completion of last platinum-based chemotherapy prior to disease relapse orprogression)
3. ECOG Performance Status of 0, 1 or 2.
4. Adequate bone marrow reserve (absolute neutrophil count (ANC) ≥1.5 x 109/L andplatelet count ≥100 x 109/L).
5. Adequate renal function defined as creatinine ≤1.5 x laboratory upper limit of normal (ULN).
6. Adequate hepatic function defined as: Bilirubin ≤1.5 x ULN ALT and AST ≤3 x ULN
7. BMI ≥19 kg/m2

Exclusion Criteria:

1. Patients with malnutrition and/ or BMI <19
2. Patients with active eating disorders (as identified by history of pre-enrollmentnutrition screen)
3. Diabetes mellitus requiring medication management (both insulin and non-insulinrequiring). Patients with diabetes mellitus controlled by diet alone (i.e. patientsnot requiring anti-glycemic medications) are NOT excluded and are eligible forparticipation.
4. Allergy to component of fasting mimicking diet (FMD)
5. Patients with recurrent ovarian, fallopian tube and primary peritoneal carcinomas withrelapse within 6 months of completion of last platinum-based chemotherapy regimen (i.e. patients with platinum-resistant disease)