A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)

Inclusion Criteria:

• Histologically or cytologically confirmed diagnosis of nonsquamous stage IV oradvanced Stage IIIB or IIIC NSCLC with KRAS p. G12C mutation and negative for PD-L1expression by central testing or local laboratory testing confirmed through centraltesting

• No history of systemic anticancer therapy in metastatic/non-curable settings

• Eastern Cooperative Oncology Group (ECOG) ≤ 1

Exclusion Criteria:

• Mixed histology NSCLC with either small-cell or large-cell neuroendocrine cellcomponent or predominant squamous cell histology

• Participants with tumors known to harbor molecular alterations for which targetedtherapy is locally approved as a front-line therapy

• Symptomatic (treated or untreated) brain metastases

• Gastrointestinal (GI) tract disease causing the inability to take oral medication

• Myocardial infarction within 6 months of randomization, unstable arrhythmias, orunstable angina

• Prior therapy with a KRAS G12C inhibitor