LIVELUNG - Impact of CGA in Patients Diagnosed With Localized NSCLC Treated With SBRT

Last updated: June 22, 2023
Sponsor: Odense University Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Non-small Cell Lung Cancer

Treatment

Comprehensive Geriatric Assessment

Clinical Study ID

NCT05919641
LIVELUNG
  • Ages > 70
  • All Genders

Study Summary

Older patients with non-small cell lung cancer (NSCLC) treated with stereotactic body radiation therapy (SBRT) often die from other causes than lung cancer due to age-related comorbidities. This national randomized study will include 130 patients throughout 5 Danish cancer centres and investigate if a comprehensive geriatric intervention (CGA) when added upfront to SBRT for patients with localized NSCLC will have an impact on quality of life (QoL), overall survival, physical functionality and unplanned hospital admissions.

If an upfront CGA improves patients' general health status, this study could lead to implementation of a CGA in standard clinical practice as well as further research on older patients receiving radiotherapy.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients with cytologically or histologically proven non-small cell lung cancer
  • Stage T1-3N0M0
  • ≥ 70 years old
  • In a multidisciplinary setting the patient is considered medically inoperable, toofrail for operation due to age and/or comorbidity or that the patient refuse surgeryand therefore candidate for SBRT.

Exclusion

Exclusion Criteria:

  • Missing histology/cytology
  • Another current malignancy
  • Higher staging at treatment planning
  • Not able to provide informed consent
  • Do not speak or understand Danish

Study Design

Total Participants: 130
Treatment Group(s): 1
Primary Treatment: Comprehensive Geriatric Assessment
Phase:
Study Start date:
September 29, 2020
Estimated Completion Date:
April 01, 2025

Connect with a study center

  • Aarhus University Hospital

    Aarhus, Aarhus N 8200
    Denmark

    Active - Recruiting

  • Rigshospitalet

    Copenhagen, 2100
    Denmark

    Active - Recruiting

  • Odense University Hospital

    Odense, 5000
    Denmark

    Active - Recruiting

  • Vejle Hospital

    Vejle, 7100
    Denmark

    Active - Recruiting

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