Phase
Condition
N/ATreatment
Furosemide
Chlorthalidone
Clinical Study ID
Ages > 18 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Adult patients (age 18 years or older), who are within their first 12 months ofchronic (expected to need dialysis for at least 6 months), in-centre hemodialysistherapy, and
Residual renal function defined as 24-hour urine volume >200cc, and
Life expectancy of at least 6 months, and
Participants must be able to understand the consent process and be able to sign aconsent form or have a substitute decision maker who is able to understand and signconsent on their behalf. In the case of non-English speaking participants, atranslator service will be used to provide study information and obtain consent.
Exclusion
Exclusion Criteria:
Unable to complete baseline urine collection
Documented allergy or adverse reaction to furosemide or chlorthalidone.
Unable to take oral medications
Patients expecting to change modality (peritoneal dialysis, home dialysis) or toreceive a renal transplant in the next 6 weeks
History of hypokalemia (<3.0 mmol/L), hypomagnesemia (<0.6mmol/L), or hypocalcaemia (<1.9mmol/L) in preceding 2 weeks.
Already participating in another study and one of the studies could interfere withthe other study
Use of loop, or thiazide diuretic medications in the last week (if a patient is onchronic diuretics, they would need to be discontinued for 1 week before starting thetrial)
Study Design
Study Description
Connect with a study center
University of Alberta
Edmonton, Alberta T6G 2B7
CanadaSite Not Available
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