SPECT-CT Vs MRI for the Diagnosis of Osteoarthritis in the Foot and Ankle

Last updated: November 21, 2024
Sponsor: Martini Hospital Groningen
Overall Status: Active - Recruiting

Phase

N/A

Condition

Osteoarthritis

Treatment

MRI

SPECT/CT

Clinical Study ID

NCT05912153
ProSPECT study
  • Ages > 18
  • All Genders

Study Summary

The diagnose of symptomatic osteoarthritis in the ankle, mid- and hind foot remains challenging. There is no gold standard for the work-up and various hospitals use different protocols. Current literature shows a promising role for SPECT-CT imaging in ankle, hind- and midfoot OA. In a previous study investigating the role of SPECT-CT in a reproducible group we have observed a change in diagnosis in 53% when SPECT-CT data was added to the data of conventional workup alone. In 26% of patients addition of SPECT-CT data resulted in change of the original treatment plan. To our knowledge no prospective studies are available on this subject for both SPECT-CT and MRI. In our clinic both SPECT-CT and MRI are used in the work-up for patients with ankle, hind- and midfoot pain. Although we experience good result with SPECT-CT, MRI might be able to detect symptomatic OA as well. Moreover MRI provide more information about soft tissue and is less harmful for the patient in comparison to SPECT-CT. The aim of this study is to determine the diagnostic performance of SPECT-CT and MRI when used routinely in patients with symptomatic OA of the ankle, hind- and midfoot.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Suspected symptomatic ankle, hind- or midfoot OA

  • Informed consent

  • Age ≥ 18 years

  • Average NRS ≥4 over the past week.

Exclusion

Exclusion Criteria:

  • Contraindication for surgery

  • Contraindication for SPECT-CT or MRI

  • Contraindication for intra-articular injections

  • Isolated forefoot pathology

  • Fracture, ligamentous or tendon injury of the ankle, hind- and/or midfoot traumawithin one year before presentation

  • History of neurological disease

  • History of foot and/or ankle surgery (affected side)

  • Inability to read and understand the written information

Study Design

Total Participants: 132
Treatment Group(s): 2
Primary Treatment: MRI
Phase:
Study Start date:
July 04, 2023
Estimated Completion Date:
June 30, 2026

Study Description

Objective: The objective is to determine diagnostic performance of SPECT-CT and MRI when used routinely in patients with symptomatic OA of the ankle, hind- and midfoot.

Study design: Prospective cohort study.

Study population: All patients ≥18years old, referred to the Martini Hospital Groningen department of Orthopedic surgery with suspected symptomatic osteoarthritis of the foot and ankle and rest pain of NRS ≥4.

Main study parameters/endpoints: Main parameters will be the diagnostic performance (a.o. sensitivity and specificity, positive and negative predictive value)of SPECT-CT and MRI.

The standard work up consist of questionnaires, detailed physical examination, conventional radiographic, MRI, SPECT-CT imaging and ultrasound guided injections. There are no additional risks for participating in this study compared to current standardised hospital workup.

Connect with a study center

  • Martini Hospital

    Groningen, 9728 NT
    Netherlands

    Active - Recruiting

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