Afimkibart (RO7790121) for the Treatment of Moderate to Severe Active Crohn's Disease

Inclusion Criteria:

• Moderately to severely active CD as defined by CDAI and SES-CD, assessed by centralread

• Elevated very soft or liquid stool frequency and/or abdominal pain

• Must have no response, insufficient response, loss of response and/or intolerance toat least 1 conventional therapy (e.g. corticosteroids) or advanced therapy

Exclusion Criteria:

• Diagnosis of ulcerative colitis, indeterminate colitis, microscopic colitis,ischemic colitis, infectious colitis, radiation colitis or active diverticulardisease

• Short gut syndrome

• Presence of an ostomy or ileoanal pouch

• Bowel resection or diversion with ~6-months