Early Detection & Intervention of Cerebral Palsy in Ireland

Last updated: September 28, 2023
Sponsor: University College Cork
Overall Status: Active - Recruiting

Phase

N/A

Condition

Cerebral Palsy

Neuronal Ceroid Lipofuscinoses (Ncl)

Holoprosencephaly

Treatment

N/A

Clinical Study ID

NCT05907837
EDI-CPI
  • Ages < 40
  • All Genders

Study Summary

Cerebral palsy (CP) is the most common lifelong physical disability. It is defined as a non-progressive disorder of movement originating from neural lesions in the perinatal period, and is associated with a wide range of common comorbidities in many individuals. These include problems speaking, hearing, seeing, thinking, feeding and controlling their bladder. People with CP often have additional challenges such as behavioural and emotional issues, pain, and poor sleep. Many of these challenges respond well to intervention in early childhood, as brain plasticity is at its greatest in the first 2 years of life. However, in most clinical settings, the age for diagnosis of CP is between 24 to 29 months, after this window of neurodevelopmental opportunity.

This project will aim to improve the Early Detection of Cerebral Palsy in Ireland. This will be achieved by implementing an evidence-based approach to follow-up of High risk infants.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Legal guardians must be able and willing to give written informed consent and tocomply with the requirements of this study protocol.
  • All infants considered high risk for cerebral palsy and neuro-developmental impairmentwill be eligible, specifically including:
  • All preterm infants born ≤32 weeks Post Menstrual Age or ≤1500 gm birth weight
  • All encephalopathic infants
  • Neurological risk factors (e.g., injury/malformation on neuroimaging,persistently abnormal neurological exam)

Exclusion

Exclusion Criteria:

  • Death prior to discharge from the neonatal unit.

Study Design

Total Participants: 1500
Study Start date:
July 01, 2023
Estimated Completion Date:
June 30, 2028

Connect with a study center

  • Cork University Maternity Hospital

    Cork,
    Ireland

    Active - Recruiting

  • Coombe Women and Infants University Hospital

    Dublin,
    Ireland

    Active - Recruiting

  • National Maternity Hospital

    Dublin,
    Ireland

    Active - Recruiting

  • The Rotunda Hospital

    Dublin,
    Ireland

    Active - Recruiting

  • University Maternity Hospital Limerick

    Limerick,
    Ireland

    Site Not Available

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