Oxygen-Enhanced MRI for Generating Hypoxia Maps in Patients With Intracranial Tumors

Inclusion Criteria:

• Adult patients (18 years of age or older) with a known or suspected intracranialtumor

• Able to provide informed written consent and/or acceptable surrogate capable ofproviding consent on the patient's behalf

• Legally authorized representative (LAR)-signed informed consent and assent obtainedfor those subjects identified as decisionally impaired

• Intracranial lesion known or suspected to be neoplastic greater than 10 mL asassessed by T2/fluid attenuated inversion recovery (FLAIR) magnetic resonance (MR)imaging

• Karnofsky performance score > 60 or Eastern Cooperative Oncology Group (ECOG) < 3 asassessed by referring clinician

• Planning to undergo or previously received therapeutic intervention for theintracranial tumor

Exclusion Criteria:

• Pregnant or breastfeeding

• Contraindication to supplemental oxygen administration, MRI, or intravenousgadolinium based contrast agents.

• Claustrophobia

• Weight greater than modality maximum capacity

• Presence of metallic foreign body or implanted medical devices in body notdocumented as MRI safe according to the Oregon Health & Science University (OHSU) Department of Radiology guidelines (including but not limited to cardiacpacemaker, aneurysm clips, surgical clips, prostheses, artificial hearts,valves with steel parts, metal fragments, shrapnel, tattoos near the eye, orsteel implants)

• Sickle cell disease

• Unsure of pregnancy status as assessed by Department of Radiology and AdvancedImaging Research Center (AIRC) guidelines

• Subjects for whom supplemental oxygen could be harmful such as people withpotential for hypoventilation or chronic respiratory insufficiency (end-stagechronic obstructive pulmonary disease [COPD], obstructive sleep apnea [OSA] oncontinuous positive airway pressure [CPAP]/biphasic positive airway pressure [Bi-PAP], etc)

• Subjects with a relative contraindication to supplemental oxygen administrationwill not be provided oxygen but may still participate in the study

• Presence of any other co-existing condition that, in the judgment of the principalinvestigator, might increase the risk to the subject (i.e., plans for hospice or endof life care)

• Poor peripheral intravenous access evaluated by patient history

• Presence of other serious systemic illnesses, including: uncontrolled infection,other uncontrolled malignancy, uncontrolled diabetes type II, or psychiatric/socialsituations which might impact the endpoint of the study or limit compliance withstudy requirements