A Study of BGB-30813 Alone or in Combination With Tislelizumab in Participants With Advanced or Metastatic Solid Tumors

Inclusion Criteria:

• Phase 1a (Dose Escalation):

• Participants with histologically or cytologically confirmed advanced,metastatic, and unresectable solid tumors who have previously receivedavailable standard systemic therapy or for whom treatment is not available ornot tolerated and who have not received any prior therapy targetingdiacylglycerol kinase (DGK)

• Eligible tumor types are immune sensitive solid tumors such as non-small celllung cancer (NSCLC), head neck squamous cell cancer (HNSCC), small cell lungcancer, hepatocellular carcinoma, esophageal cancer, gastric orgastroesophageal carcinoma, nasopharyngeal carcinoma, triple-negative breastcancer, urothelial carcinoma, renal cell carcinoma, cervical cancer,endometrial carcinoma, cutaneous squamous cell carcinoma, melanoma, Merkel cellcarcinoma, mesothelioma, microsatellite instability (MSI)-high, tumor mutationburden (TMB)-high, or mismatch repair deficient solid tumors

• Prior checkpoint inhibitor (CPI) therapy is allowed

• Phase 1b (Dose Expansion):

• Participants with selected advanced or metastatic solid tumors including NSCLC,HNSCC, and additional potential tumor types to be defined based on emergingdata

• ≥ 1 measurable lesion per RECIST v1.1

• Eastern Cooperative Group Oncology Performance (ECOG) Performance Status score ≤ 1

• Females of childbearing potential must be willing to use a highly effective methodof birth control for the duration of the study

• Adequate organ function as indicated by the following laboratory values up to firstdose of study treatment: Hemoglobin≥ 90 grams per liter (g/L), Absolute neutrophilcount ≥ 1.5 x 109/L , Serum total bilirubin ≤ 1.5 x upper limit of normal (ULN) (< 3x ULN for participants with Gilbert syndrome ), aspartate aminotransferase (AST) andalanine aminotransferase (ALT) ≤ 2.5 x ULN

Exclusion Criteria:

• Previous therapy targeting DGK

• Active leptomeningeal disease or uncontrolled symptomatic central nervous system (CNS) metastasis

• Active autoimmune diseases or history of autoimmune diseases that may relapse

• Any active malignancy ≤ 2 years before the first dose of study treatment except forthe specific cancer under investigation in this study and any locally recurringcancer that has been treated with curative intent

• Systemic anticancer therapy, including chemotherapy ≤ 21 days or 5 half-lives (whichever is shorter) before the first dose of study drugs

• ≥ Grade 3 immune-mediated adverse events on prior immuno-oncology agent (anti-PD-1or anti-CTLA4 antibodies or other experimental drugs)

Note: Other protocol-defined Inclusion/Exclusion criteria may apply.