Gastric Volume in Patients on GLP-1 Medications

Last updated: March 17, 2025
Sponsor: Children's Hospital of Philadelphia
Overall Status: Completed

Phase

N/A

Condition

Diabetic Neuropathy

Diabetic Vitreous Hemorrhage

Diabetic Macular Edema

Treatment

None - observational

Clinical Study ID

NCT05903482
23-021125
  • Ages < 18
  • All Genders

Study Summary

Evaluating gastric volume in patients on GLP-1 RA medications

Eligibility Criteria

Inclusion

Inclusion Criteria:

Fasting Diabetic On GLP-1 RA

Exclusion

Exclusion Criteria:

Prior surgery that affects gastric anatomy

Study Design

Total Participants: 70
Treatment Group(s): 1
Primary Treatment: None - observational
Phase:
Study Start date:
June 06, 2023
Estimated Completion Date:
December 31, 2024

Study Description

Glucagon like peptide 1 (GLP-1) receptor agonist (RA) medications have in recent years been approved for use in children with type 2 diabetes mellitis (DM) and obesity. The side effects of these medications include nausea and vomiting, and in the adult literature, delayed gastric emptying has been described. Due to the likelihood of delayed enteric motility, standard nil per os (NPO) guidelines may not be sufficient to minimize the chance of aspiration of gastric contents before anesthesia and surgery in patients receiving GLP-1 RA medications.

Investigators seek to measure the gastric volume of children on GLP-1 RA medications who are appropriately NPO (greater than/equal to 8 hours for solids and greater than/equal to 1 hour for clear liquids) using standard institutional NPO guidelines. The secondary objective is to measure the gastric volume of children not on GLP-1 RA medications, but with type 2 diabetes mellitis or obesity and/or type 1 DM.

The only study intervention is the addition of a gastric ultrasound. The gastric ultrasound is a non-invasive mode of imaging using sound waves with no known safety risks. The ultrasound will be performed while the subject is awake and will take less than 5 minutes.

Connect with a study center

  • Children's Hospital of Philadelphia

    Philadelphia, Pennsylvania 19004
    United States

    Site Not Available

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