SVRd for the Treatment of Newly Diagnosed Multiple Myeloma Patients Presenting With Extramedullary Disease

Inclusion Criteria:

1. Men and women aged with18-75 years old.

2. Confirmed diagnosis of Multiple Myeloma(MM) (IMWG consensus guidelines)

3. Newly diagnosed patients presenting with extramedullary disease (EMD) includingsolely paraskeletal plasmacytoma, plasmacytoma of soft tissue and other specialsites detected by physical exam and confirmed by CT/MRI/PET-CT and/or biopsy (≥2cm).

4. ANC≥1.010^9/L, HGB≥7510^9/L, PLT≥50*10^9/L (≥50% of bone marrow nucleated cellsare plasma cells).

5. Patients whose expecting survival time will be more than 3 months.

6. Without active infectious disease.

7. Female patients of child-bearing potential must have a negative serum pregnancy testat screening and all patients agree to use two reliable methods of contraception forsix months after their last dose of medication.

8. Willingness and ability to comply with scheduled visits, treatment plans, laboratorytests and other study procedures.

9. Each patient must sign an informed consent form (ICF) indicating that he or sheunderstands the purpose of and procedures required for the study and are willing toparticipate in the study.

Exclusion Criteria:

1. Patients who have HBV, HCV, and other acquired and congenital immunodeficiencydiseases.

2. Patients who have grade 2 or higher of peripheral neuropathy or neuralgia accordingto the definition of NCI CTCAE version 4.0.

3. Plasma cell leukemia.

4. Serious thrombotic events.

5. Active, unstable cardiovascular dysfunction: a. symptomatic ischemia; b.Uncontrolled, clinically significant conduction abnormalities (except antiarrhythmicventricular tachycardia), but patients with first-degree atrioventricular block orasymptomatic left anterior bundle/right fascicular block cannot be excluded. c. NewYork Heart Association (NYHA) Class III - IV or left ventricular ejection fraction (LVEF) <40%; d. Myocardial infarction Within 3 months before C1D1.

6. Significant hepatic dysfunction (ALT and AST ≥ 3 times the upper limit of normal (ULN)).

7. Serum bilirubin≥1.5 × ULN.

8. creatinine clearance <30 ml/min.

9. History of active malignancy during the past 5 years with the exception of basalcarcinoma of the skin or stage 0 cervical carcinoma.

10. Previous major operation within 30 days before C1D1.

11. Patients who have epilepsy, dementia requiring medication, or other mental disorderswho are unable to understand or adhere to the study protocol.

12. According to the study protocol or in the opinion of the investigator,seriousphysical or mental illness that is likely to interfere with the studyprocedures/results.

13. Any psychological, familial, sociological and geographical condition potentiallyhampering compliance with the study protocol and follow-up schedule.

14. Current participation in another clinical trial.

15. Pregnant or lactating women.

16. Patients with other commodities that the investigators considered not suitable forthe enrollment.