Comparison of the Effectiveness of Two Different Surgical Therapeutic Protocols of Peri-implantitis

Inclusion Criteria:

General Inclusion Criteria:

• Participants ≥ 18 years and ≤ 80 years of age

• Non-smokers based on the patients' self-reported smoking status, defined as patientswho had never smoked or had quit smoking at least 2 years ago

• Implants in function for more than 1 year after suprastructure connection

Inclusion Criteria for implants diagnosed with Peri-Implantitis:

• Presence of at least one implant diagnosed with peri-implantitis defined as presenceof bleeding on probing and/or suppuration, probing pocket depth ≥6 mm and ≥3 mm ofdetectable bone loss after initial re-modelling

• Absence of implant mobility

• in participants with more than one implant, the implant with the worst clinicalcondition will be studied.

Inclusion Criteria for implants diagnosed with Peri-Implant Health:

• Absence of peri-implant signs of inflammation (redness, swelling)

• Lack of bleeding on probing

• Absence of bone loss beyond crestal bone level changes resulting from initialremodeling, which should not be ≥2 mm

Exclusion Criteria:

• Smokers

• Uncontrolled diabetes mellitus (HBA1c >7)

• Treatment with bisphosphonates

• Needing antibiotic prophylaxis

• Currently pregnant or breast-feeding women

• History of systemic administration of antibiotic treatment during the preceding 3months

• Systemic conditions that contraindicate treatment

• Use of medications known to induce gingival hyperplasia