ITEST: Introspective Accuracy As a Novel Target for Functioning in Psychotic Disorders

Last updated: March 24, 2025
Sponsor: University of California, San Diego
Overall Status: Active - Recruiting

Phase

N/A

Condition

Tourette's Syndrome

Schizotypal Personality Disorder (Spd)

Schizophrenia And Schizoaffective Disorders (Pediatric)

Treatment

iTEST

Clinical Study ID

NCT05899348
1R61MH129379-01A1
  • Ages 18-65
  • All Genders

Study Summary

People with psychotic disorders experience a high level of functional disability, and a major contributor to this disability is introspective accuracy, which is defined as inaccurate judgements of one's abilities and performance on tasks. Yet, no intervention has directly targeted introspective accuracy for psychotic illnesses. This trial will evaluate a new intervention, called iTEST, that uses mobile devices to train people with psychotic disorders to improve introspective accuracy and, ultimately, functional outcomes

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Voluntary informed consent to participate and capacity to consent as measured by theUCSD Brief Assessment of Capacity to Consent (UBACC)

  2. Age 18 to 65;

  3. DSM-5 diagnosis of schizophrenia or schizoaffective disorder based on a structureddiagnostic interview and available medical record review;

  4. ≥ 6th grade reading level on the Wide Range Achievement Test-4 Reading subtest (needed to read instructions on device);

  5. Stable co-treatments (no hospitalizations or medication class changes in 2 monthsbefore enrollment). The investigators will determine symptom and medicationstability by best-estimate history with information from medical records;

  6. Availability of a clinician (staff member, case manager, other mental healthclinician) or close associate (family member, friend) with at least monthly contactwho can be their informant

  7. Minimum level of functional impairment based on milestones, excluding participantswho are full-time employed and financially responsible for their household.

Exclusion

Exclusion Criteria:

  1. Greater than moderate disorganization on the Positive and Negative Syndrome Scale (P2-Disorganization item >5)

  2. DSM-5 alcohol or substance dependence in past 3 months based on interview

  3. Level of care required interferes with outpatient therapy (e.g., hospitalized;severe medical illness); 4) Unable to adequately see or manually manipulate asmartphone.

Study Design

Total Participants: 60
Treatment Group(s): 1
Primary Treatment: iTEST
Phase:
Study Start date:
October 01, 2023
Estimated Completion Date:
August 01, 2025

Study Description

This NIH-supported clinical trial is the first phase of a two phase program, funded by Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders, R61/R33. The overarching goal is to evaluate a new blended mobile intervention that is aimed at improving introspective accuracy (IA) in people with psychotic disorders, with the ultimate goal of improving functional outcome. Introspective accuracy is the degree to which one's self-assessment of performance or abilities corresponds with objective data. Recent research indicates that poor IA is an independent predictor of functional disability. Yet, there are currently no treatments that directly target IA. Basic experimental research and other lines of evidence suggest IA is malleable, and that improvement in task-based IA transfers to untrained tasks. This project's premise is that task-based IA training could be delivered in a remote mobile health format and coupled with coaching in applying improved IA to real-world functional behaviors, creating a novel avenue for functional rehabilitation in psychotic disorders. The investigators have developed and completed usability testing of iTEST, a novel blended IA targeted mobile intervention. iTEST integrates graduated drill-and-practice training in IA delivered on a mobile device with personalized coaching in applying IA to everyday compensatory behaviors. In the R61 phase trial here, the investigators will recruit people with psychotic disorders with at least minimal functional impairment. The investigators will conduct an open trial of iTEST, evaluating whether the intervention leads to clinically significant changes in task-based IA along with transfer to an untrained task (target mechanisms). The investigators will also determine the dose of intervention needed to achieve clinically significant improvement in IA targets, by evaluating change at 8, 12, or 16 weeks. The go/no go criteria for this trial are 75% adherence and clinically significant increases in introspective accuracy. A total of 60 persons who are diagnosed with schizophrenia or schizoaffective disorder will be recruited into this trial

Connect with a study center

  • University of California, San Diego

    La Jolla, California 92037
    United States

    Active - Recruiting

  • University of Texas at Dallas

    Richardson, Texas 75080
    United States

    Active - Recruiting

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