Low-Intensity Mechanical Stimulation for Hematologic Malignancy Patients

Inclusion Criteria:

• COHORT I: Meet eligibility criteria for first autologous or allogeneic HCT (patientswith preexisting osteoporosis are eligible)

• COHORT I: Scheduled to undergo an autologous or allogeneic HCT

• COHORT 1: >= 18 years of age

• COHORT 1: Patient must understand the investigational nature of this study and signan institutional review board approved written informed consent form prior toreceiving any study related procedure

• COHORT II: ≥ 18 years of age

• COHORT II: Diagnosis of non-Hodgkin lymphoma (specifically diffuse large B-celllymphoma, follicular lymphoma, mantle cell lymphoma, chronic lymphocytic leukemia;patients with preexisting osteoporosis are eligible)

• COHORT II: Patient must understand the investigational nature of this study and signan Institutional Review Board approved written informed consent form prior toreceiving any study related procedure

Exclusion Criteria:

COHORT 1:

• Any prior allogeneic HCT

• Any prior autologous HCT for those patients who have a planned auto HCT

• Pre-transplant weight >= 275 lbs. (max weight for the board)

• Body mass index (BMI) < 18 kg/m^2

• Recipient of cord blood transplant

• Multiple myeloma or amyloidosis diagnosis

• History of a central nervous system (CNS) hemorrhage < 60 days

• History of any aneurysm (cerebral, aortic, etc.)

• A recent pulmonary embolism or deep vein thrombosis

• A cardiac pacemaker

• Prior history of non-traumatic (spontaneous) fracture

• Total joint replacement (any joint)

• History of kidney stones or gall stones within the last 2 years unless acholecystectomy was performed

• Any prosthetic lower extremity or limb

• Pregnant or nursing female patients

• Unwilling or unable to follow protocol requirements

• Any condition which in the Investigator's opinion deems the patient an unsuitablecandidate to receive study intervention

COHORTII:

• Planned CAR T-cell therapy within the next 2 months

• Prior CAR T-cell therapy

• Active treatment within the last 60 days

• Pre-transplant weight ≥ 275 lbs. (max weight for the board)

• BMI < 18 kg/m^2

• History of a CNS hemorrhage < 60 days

• History of any aneurysm (cerebral, aortic, etc.)

• A recent pulmonary embolism or deep vein thrombosis

• A cardiac pacemaker

• Recent history (< 60 days) of non-traumatic (spontaneous) fracture

• Recent surgery (< 60 days)

• Pregnant or nursing female patients

• Unwilling or unable to follow protocol requirements

• Any condition which in the investigator's opinion deems the patient an unsuitablecandidate to receive study intervention