Advancing Cath Lab Results With FFRangio Coronary Physiology Assessment

Inclusion Criteria:

1. Adult patient ( ≥18 years old) presenting with CCS or NSTEACS with one or more studylesion(s) deemed appropriate (diameter stenosis 50-90%) for both pressure-wire andFFRangio physiologic assessment.

General Exclusion Criteria:

1. Subject with ST-elevation (MI (STEMI) within 72 hours at time of study enrollment

2. Prior coronary artery bypass graft (CABG) with patent grafts to the study vessel(s)

3. Patients undergoing coronary physiologic assessment where one possible outcome isreferral for CABG

4. The study vessel supplies a significant nonviable territory (e.g., prior transmuralMI)

5. Severe left sided valvular heart disease

6. Most recent documented LVEF ≤30%

7. Women who are pregnant or breastfeeding (women of childbearing potential arerequired to have negative pregnancy test within 1 week of index procedure)

8. Patients with life expectancy <1 year life as estimated by treating physician.

9. Subjects enrolled in other ongoing non-registry clinical studies that would impactconduct or outcomes of this study (registries and long-term follow-up of otherstudies are allowed)

10. Subjects who have undergone angiographic or wire-based coronary physiologicalassessment for 1 or more potential study lesions within 30 days of enrollment.