Phase
Condition
Macular Degeneration
Geographic Atrophy
Treatment
CLS-AX
Aflibercept
Clinical Study ID
Ages > 50 All Genders
Study Summary
Eligibility Criteria
Inclusion
Key Inclusion Criteria:
Diagnosis of neovascular age-related macular degeneration (nAMD) in the study eyewithin 36 months of Visit 1.
Subfoveal choroidal neovascularization (CNV) secondary to nAMD of any lesion type inthe study eye that shows total lesion area ≤30 mm2, CNV component area of ≥50% ofthe total lesion area, and and CNV must not be associated with subfoveal hemorrhage,subfoveal fibrosis, or subfoveal atrophy.
Previous treatment in the study eye with between 2 and 4 anti-VEGF intravitrealinjections for nAMD (faricimab, ranibizumab, bevacizumab, brolucizumab, oraflibercept) per standard of care within 6 months of Visit 1.
History of response to prior intravitreal anti-VEGF treatment in the study eye.
ETDRS BCVA of between 20 and 80 letters (inclusive) in the study eye.
Exclusion
Key Exclusion Criteria:
ETDRS BCVA <20 letters in the study eye.
Central subfield thickness > 400 μm or retinal pigment epithelium detachmentthickness >400 μm on SD-OCT in the study eye.
Subretinal hemorrhage, fibrosis or atrophy of >50% of the total lesion area and/orthat involves the fovea on fundus fluorescein angiography and/or color fundusphotography in the study eye.
CNV due to causes other than AMD, such are ocular histoplasmosis, trauma,pathological myopia, angioid streaks, choroidal rupture, or uveitis, in the studyeye.
Any history of macular pathology unrelated to AMD affecting vision or contributingto the presence of intraretinal or subretinal fluid in the study eye.
Study Design
Study Description
Connect with a study center
Associated Retina Consultants
Phoenix, Arizona 85020
United StatesSite Not Available
Retinal Research Institute, LLC
Phoenix, Arizona 85053
United StatesSite Not Available
California Retina Consultants
Bakersfield, California 93309
United StatesSite Not Available
Retina Consultants of Orange County
Fullerton, California 92835
United StatesSite Not Available
Northern California Retina Vitreous Associates Medical Group, Inc
Mountain View, California 94040
United StatesSite Not Available
Retina Consultants San Diego
Poway, California 92064
United StatesSite Not Available
Retinal Consultants of Southern California
Redlands, California 92374
United StatesSite Not Available
Retinal Consultants Medical Group, Inc.
Sacramento, California 95825
United StatesSite Not Available
Retina Group of Florida
Fort Lauderdale, Florida 33308
United StatesSite Not Available
Florida Retina Consultants
Lakeland, Florida 33805
United StatesSite Not Available
Retina Specialty Institute
Pensacola, Florida 32503
United StatesSite Not Available
Retina Associates of Florida
Tampa, Florida 33609
United StatesSite Not Available
Southeast Retina Center
Augusta, Georgia 30909
United StatesSite Not Available
Georgia Retina, PC
Marietta, Georgia 30060
United StatesSite Not Available
Illinois Retina Associates
Oak Park, Illinois 60304
United StatesSite Not Available
Wolfe Eye Clinic
Des Moines, Iowa 50266
United StatesSite Not Available
Cumberland Valley Retina Consultants
Hagerstown, Maryland 21740
United StatesSite Not Available
Vitreo-Retinal Associates, PC
Worcester, Massachusetts 01605
United StatesSite Not Available
Sierra Eye Associates
Reno, Nevada 89431
United StatesSite Not Available
Envision Ocular LLC
Bloomfield, New Jersey 07003
United StatesSite Not Available
Western Carolina Retinal Associates P.A.
Asheville, North Carolina 28803
United StatesSite Not Available
Tennessee Retina PC
Nashville, Tennessee 37203
United StatesSite Not Available
Retina Research Institute of Texas
Abilene, Texas 79606
United StatesSite Not Available
Texas Retina Associates - Arlington
Arlington, Texas 76012
United StatesSite Not Available
Austin Retina
Austin, Texas 78705
United StatesSite Not Available
Retina Consultants of Texas-Bellairre
Bellaire, Texas 77401
United StatesSite Not Available
Texas Retina Associates - Dallas
Dallas, Texas 75231
United StatesSite Not Available
Retina Consultants of Texas - Katy
Katy, Texas 77494
United StatesSite Not Available
Texas Retina Associates
Plano, Texas 75075
United StatesActive - Recruiting
Texas Retina Associates-Plano
Plano, Texas 75075
United StatesSite Not Available
Retina Consultants of Texas
San Antonio, Texas 78240
United StatesActive - Recruiting
Retina Consultants of Texas-San Antonio
San Antonio, Texas 78240
United StatesSite Not Available
Retina Group of Washington
Fairfax, Virginia 22031
United StatesSite Not Available
Spokane Eye Clinical Research
Spokane, Washington 99204
United StatesSite Not Available
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