Research Study Looking at How Well Semaglutide Tablets Taken Once Daily Work in Chinese Adults Who Are Above a Healthy Weight Range (OASIS 3)

Inclusion Criteria:

• Informed consent obtained before any study-related activities. Study-relatedactivities are any procedures that are carried out as part of the study, includingactivities to determine suitability for the study.

• Male or female, age greater than or equal to 18 years at the time of signinginformed consent.

• Body mass index (BMI) of

1. greater than or equal to 28.0 kilogram per meter square (kg/m^2) or

2. greater than or equal to 24.0 kg/m^2 with greater than or equal to 1weight-related comorbidity (treated or untreated). Weight-related comorbiditiesshould be hypertension, T2D, dyslipidaemia, obstructive sleep apnoea orcardiovascular disease.

• History of at least one self-reported unsuccessful dietary effort to lose bodyweight.

For participants with T2D at screening the following inclusion criteria apply in addition to criteria 1- 4:

• Diagnosed with T2D greater than or equal to 180 days prior to screening.

• Treated with either diet and exercise alone or stable treatment (same drug(s) oractive ingredient, dose and dosing frequency) for at least 60 days prior to the dayof screening with up to 3 oral antidiabetic drugs (OAD)s alone or in any combination (metformin, α-glucosidase (AGI), sulphonylureas (SU), glinides, SGLT2i (sodium-glucose co-transporter 2 inhibitor) or glitazone).

• HbA1c 7.0 - 10.0 percent (53 - 86 millimoles per mole [mmol/mol]) (both inclusive)as measured by central laboratory at screening.

Exclusion Criteria:

Participants without T2D at screening:

• HbA1c greater than or equal to 6.5 percent (48 mmol/mol) as measured by the centrallaboratory at screening.

• History of type 1 or type 2 diabetes.

• Treatment with glucose-lowering agent(s) within 90 days prior to screening.

Participants with T2D at screening:

• Uncontrolled and potentially unstable diabetic retinopathy or maculopathy. Verifiedby a fundus examination performed by an ophthalmologist or another suitablyqualified health care provider within the past 90 days prior to screening or in theperiod between screening and randomisation. Pharmacological pupil-dilation is arequirement unless using a digital fundus photography camera specified fornon-dilated examination.

• Renal impairment measured as estimated glomerular filtration rate (eGFR) value oflesser than 30 milli litre per min/1.73 square metre (mL/min/1.73 m^2) according toChronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine equation asdefined by Kidney Disease Improving Global Outcomes (KDIGO) 2012 classification bythe central laboratory at screening.