Colchicine After Electrocardioversion for Atrial Fibrillation

Inclusion Criteria:

• Age >18 years

• ECG-documented AF prior to ECV

• Successful ECV with conversion of AF to sinus rhythm with persistent sinus rhythm ≥30 minutes after ECV

• Ability to give written informed consent

Exclusion Criteria:

• AF persistence after cardioversion or early AF recurrence within 30 minutes afterECV

• Any other rhythm than AF before cardioversion

• Pulmonary vein isolation within 3 months prior to ECV or pulmonary vein isolationplanned within 3 months after ECV

• Known intolerance or hypersensitivity to Colchicine

• Any other absolute indication for Colchicine intake

• Intake of a strong inhibitor of CYP3A4 or P-Glycoprotein (clarithromycin,erythromycin, telithromycin, cyclosporine, ketoconazole or itraconazole)

• Serious gastrointestinal disease (severe gastritis or diarrhea)

• Clinically overt hepatic disease

• Severe renal disease (eGFR< 30ml/min/1.73m2)

• Clinically significant blood dyscrasia (e.g., myelodysplasia)

• Significant immunosuppression (e.g. due to transplantation or rheumatic disease)

• Pregnant or breastfeeding women, or women of child-bearing potential who do not usea highly effective form of birth control

• Life expectancy <1 year