Influence of Local Doxycycline on the Outcomes of Periodontal Regeneration

Last updated: July 31, 2024
Sponsor: University of Turin, Italy
Overall Status: Completed

Phase

N/A

Condition

N/A

Treatment

Decontamination of the pocket with local doxycycline

Decontamination of the pocket with mechanical instrumentation

Clinical Study ID

NCT05878353
DoxyTurin
  • Ages > 18
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

In this double-blinded randomized clinical trial, patients presenting periodontal intrabony defects requiring regenerative surgery and showing BoP will be included. Experimental sites at T-0 will be randomly treated with gentle debridement and administration of local DOX (test group) or with debridement alone (control group). After 2 weeks (T-1), defects will be treated by means of minimally invasive surgical technique. 14 days after the surgery (T-2) the EHI will be evaluated by a blinded examiner. Patients will be recalled each 2 months up to 12 months (T-3). At T-0, T-1 and T-3 periodontal examination and radiographic analysis will be done.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. diagnosis of Stage III or IV periodontitis (Tonetti et al. 2018);
  1. FMPS and FMBS < 15% at the time of enrollment;
  1. etiological periodontal therapy completed at least 3 months prior to screening;
  1. presence of one natural tooth having a vertical defect with residual PPD ≥ 6 mmand a radiographic intrabony component ≥ 3 mm and BoP + requiring periodontalregenerative surgery.

Exclusion

Exclusion Criteria:

  1. age < 18 years;
  1. smoking habits (> 10 cigarettes/day);
  1. contraindications for periodontal surgery;
  1. systemic diseases affecting periodontal healing;
  1. pregnancy and lactation;
  1. history of periodontal surgery at the experimental teeth;
  1. allergies to doxycycline and tetracyclines;
  1. assumption of antibiotics in the last 3 months.

Study Design

Total Participants: 60
Treatment Group(s): 2
Primary Treatment: Decontamination of the pocket with local doxycycline
Phase:
Study Start date:
May 30, 2023
Estimated Completion Date:
July 15, 2024

Connect with a study center

  • CIR Dental School

    Turin, 10126
    Italy

    Site Not Available

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