Sodium Channel Mutations in Patient With the Anterior Cutaneous Nerve Entrapment Syndrome (ACNES)

Last updated: October 26, 2023
Sponsor: Maxima Medical Center
Overall Status: Active - Recruiting

Phase

N/A

Condition

Peripheral Neuropathy

Fibromyalgia

Chronic Pain

Treatment

Sodium channel mutation

Clinical Study ID

NCT05877274
NL84021.015.23
  • Ages > 18
  • All Genders

Study Summary

The goal of this observational study is to learn about sodium channel (Nav) mutations in patients with the Anterior Cutaneous Nerve Entrapment Syndrome (ACNES). This study will give more insight into the pathophysiology of ACNES, which is still largely unknown.

The primary objective is to determine if there are mutations of Nav1.7 and Nav1.8 in patients with ACNES. Therefore, one blood sample will be drawn, in which the mutations will be analyzed.

Eligibility Criteria

Inclusion

Inclusion Criteria: In order to be eligible to participate in this study, a subject must be diagnosed withACNES and receive treatment at our outpatient clinic. Additionally, subject has to meet oneof the following criteria:

  • Known to have a first- or second-degree relative with ACNES;
  • Have more than one recurrence of ACNES after a pain free period or ACNES at multiplelocations in the abdominal wall;
  • Persistent pain after posterior neurectomy.

Exclusion

Exclusion Criteria:

  • Inability to understand Dutch language.
  • Known neuromuscular or neurodegenerative disease.

Study Design

Total Participants: 50
Treatment Group(s): 1
Primary Treatment: Sodium channel mutation
Phase:
Study Start date:
October 03, 2023
Estimated Completion Date:
December 31, 2024

Connect with a study center

  • Maxima Medical Center

    Veldhoven, 5504 DB
    Netherlands

    Active - Recruiting

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