A Study of Orforglipron in Adult Participants With Obesity or Overweight and Type 2 Diabetes

Inclusion Criteria:

• Have a body mass index (BMI) ≥27.0 kilogram/square meter (kg/m²).

• Have a history of at least 1 self-reported unsuccessful dietary effort to lose bodyweight.

• Have a diagnosis of Type 2 Diabetes (T2D), with HbA1c ≥7% (≥53 mmol/mol) to ≤10% (86mmol/mol) and are on stable treatment for T2D for at least 90 days prior toscreening, consisting of:

• either diet/exercise alone or

• up to 3 oral antihyperglycemic medications (excluding dipeptidyl peptidase IVinhibitors (DPP-4i) or glucagon-like peptide-1 (GLP-1) receptor agonists (RA).

Exclusion Criteria:

• Have Type 1 Diabetes (T1D), history of ketoacidosis or hyperosmolar state/coma, orany other types of diabetes except T2D.

• Have a self-reported change in body weight >5 kg (11 pounds) within 90 days prior toscreening.

• Are currently receiving or planning to receive treatment for diabetic retinopathyand/or macular edema (for example, laster photocoagulation or intravitrealinjections of anti-vascular endothelial growth factor inhibitors).

• Have family (first-degree relative) or personal history of medullary thyroid cancer (MTC) or multiple endocrine neoplasia 2 (MEN2) syndrome.

• Have had a history of chronic or acute pancreatitis.