Phase
Condition
Obesity
Diabetes Mellitus, Type 2
Diabetes And Hypertension
Treatment
Placebo
Orforglipron
Clinical Study ID
Ages > 18 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Have a body mass index (BMI) ≥27.0 kilogram/square meter (kg/m²).
Have a history of at least 1 self-reported unsuccessful dietary effort to lose bodyweight.
Have a diagnosis of Type 2 Diabetes (T2D), with HbA1c ≥7% (≥53 mmol/mol) to ≤10% (86mmol/mol) and are on stable treatment for T2D for at least 90 days prior toscreening, consisting of:
either diet/exercise alone or
up to 3 oral antihyperglycemic medications (excluding dipeptidyl peptidase IVinhibitors (DPP-4i) or glucagon-like peptide-1 (GLP-1) receptor agonists (RA).
Exclusion
Exclusion Criteria:
Have Type 1 Diabetes (T1D), history of ketoacidosis or hyperosmolar state/coma, orany other types of diabetes except T2D.
Have a self-reported change in body weight >5 kg (11 pounds) within 90 days prior toscreening.
Are currently receiving or planning to receive treatment for diabetic retinopathyand/or macular edema (for example, laster photocoagulation or intravitrealinjections of anti-vascular endothelial growth factor inhibitors).
Have family (first-degree relative) or personal history of medullary thyroid cancer (MTC) or multiple endocrine neoplasia 2 (MEN2) syndrome.
Have had a history of chronic or acute pancreatitis.
Study Design
Connect with a study center
CEMEDIAB
C.a.b.a., Ciudad Aut C1205AAO
ArgentinaSite Not Available
Instituto Centenario
Caba, Ciudad Autónoma De Buenos Aire 1204
ArgentinaSite Not Available
Mautalen Salud e Investigación
Buenos Aires, Ciudad Autónoma De Buenos Aires C1128AAF
ArgentinaSite Not Available
Instituto Médico Fundación Grupo Colaborativo Rosario Investigación y Prevención Medica
Rosario, Santa Fe 2000
ArgentinaSite Not Available
Instituto de Investigaciones Clinicas Rosario
Rosario, Santa Fe 2000
ArgentinaSite Not Available
Sanatorio San Martin
Venado Tuerto, Santa Fe 2600
ArgentinaSite Not Available
Centro Medico Privado de Reumatologia
SAN M. DE Tucuman, Tucumán T4000AXL
ArgentinaSite Not Available
Centro de Investigaciones Médicas Tucuman
SAN M. DE Tucuman, Tucumán T4000AXL
ArgentinaSite Not Available
Centro de Investigaciones Médicas Tucuman
San Miguel De Tucumán, Tucumán T4000AXL
ArgentinaSite Not Available
CONEXA Investigacion Clinica S.A.
Buenos Aires, 1012
ArgentinaSite Not Available
Centro Diabetológico Dr. Waitman
Córdoba, 5000
ArgentinaSite Not Available
Clínica Universitaria Reina Fabiola
Córdoba, X50004FHP
ArgentinaSite Not Available
Centro de Diagnóstico y Rehabilitación (CEDIR)
Santa Fe, 3000
ArgentinaSite Not Available
Emeritus Research
Botany, New South Wales 2019
AustraliaSite Not Available
Optimus Clinical Research
Botany, New South Wales 2019
AustraliaSite Not Available
The AIM Centre / Hunter Diabetes Centre
Merewether, New South Wales 2291
AustraliaSite Not Available
Core Research Group
Brisbane, Queensland 4064
AustraliaSite Not Available
Royal Brisbane and Women's Hospital
Brisbane, Queensland 4029
AustraliaSite Not Available
Logan Hospital
Meadowbrook, Queensland 4131
AustraliaSite Not Available
Southern Adelaide Diabetes & Endocrine Services
Oaklands Park, South Australia 5046
AustraliaSite Not Available
Box Hill Hospital
Box Hill, Victoria 3128
AustraliaSite Not Available
Emeritus Research
Camberwell, Victoria 3124
AustraliaSite Not Available
Austin Health - Repatriation Hospital
Heidelberg West, Victoria 3081
AustraliaSite Not Available
Baker Heart and Diabetes Institute
Melbourne, Victoria 3004
AustraliaSite Not Available
Baker IDI Heart and Diabetes Institute - Melbourne
Melbourne, Victoria 3004
AustraliaSite Not Available
Advara HeartCare Joondalup
Joondalup, Western Australia 6027
AustraliaSite Not Available
GenesisCare
Joondalup, Western Australia 6027
AustraliaSite Not Available
Centro de Pesquisa Clinica do Brasil
Brasilia, Distrito Federal 71625-175
BrazilSite Not Available
Cendi - Endocrinologia e Diabetes
Goiânia, Goiás 74230-035
BrazilSite Not Available
Instituto Lóbus
Volta Redonda, Rio De Janeiro 27253-003
BrazilSite Not Available
Instituto Méderi de Pesquisa e Saúde
Passo Fundo, Rio Grande Do Sul 99010-120
BrazilSite Not Available
Instituto de Pesquisa clinica de Campinas
Campinas, São Paulo 13060-080
BrazilSite Not Available
Centro de Pesquisa Clínica de Marília - CPCLIM
Marília, São Paulo 17504-072
BrazilSite Not Available
Pesquisare Saude
Santo André, São Paulo 09080-110
BrazilSite Not Available
CEPIC - Centro Paulista de Investigação Clínica
São Paulo, 04266-010
BrazilSite Not Available
Hospital das Clinicas FMUSP
São Paulo, 04266-010
BrazilSite Not Available
The Second People's Hospital of Hefei
Hefei, Anhui 230011
ChinaSite Not Available
Chinese PLA General Hospital
Beijing, Beijing 100853
ChinaSite Not Available
Chongqing General Hospital
Chongqing, Chongqing 400014
ChinaSite Not Available
ShenZhen People's Hospital
Shenzhen, Guangdong 518020
ChinaSite Not Available
Hainan General Hospital
Haikou, Hainan 570311
ChinaSite Not Available
The Fourth Affiliated Hospital of Harbin Medical University
Harbin, Heilongjiang 150001
ChinaSite Not Available
The Fourth Hospital of Harbin Medical University
Harbin, Heilongjiang 150001
ChinaSite Not Available
The First Affiliated Hospital of Henan University of Science &Technology
Luoyang, Henan 471003
ChinaSite Not Available
The First Affiliated Hospital of Henan University of Science &Technology
Luoyang Shi, Henan 471003
ChinaSite Not Available
The Second Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan 450014
ChinaSite Not Available
Jiangsu Province Official Hospital
Nanjing, Jiangsu 210008
ChinaSite Not Available
Nanjing First Hospital
Nanjing, Jiangsu 210006
ChinaSite Not Available
The Second Affiliated Hospital of Nanjing Medical University
Nanjing, Jiangsu 210011
ChinaSite Not Available
Nantong First People's Hospital
Nantong, Jiangsu 226001
ChinaSite Not Available
Wuxi People's Hospital
Wuxi, Jiangsu 214023
ChinaSite Not Available
Jiangxi Provincial People's Hospital
Nanchang, Jiangxi 330006
ChinaSite Not Available
Dalian Municipal Central Hospital Affiliated of Dalian Medical University
Dalian, Liaoning 116033
ChinaSite Not Available
Jinan Central Hospital
Jinan, Shandong 250013
ChinaSite Not Available
Tianjin Medical University General Hospital
Tianjin, Tianjin 300052
ChinaSite Not Available
Tianjin Medical University Zhu Xianyi Memorial Hospital
Tianjin, Tianjin
ChinaSite Not Available
The First People's Hospital of Yunnan Province
Kunming, Yunnan 650034
ChinaSite Not Available
MUDr. Alena Vachova
Ceske Budejovice, Jihočeský 37011
CzechiaSite Not Available
MUDr. Tomas Edelsberger
Krnov, Moravskosl 79401
CzechiaSite Not Available
Diahelp s.r.o
Pardubice V, Pardubice 530 02
CzechiaSite Not Available
Dialine - Interni a diabetologicka ambulance
Pilsen, Plzeň-město 301 00
CzechiaSite Not Available
Diabet2 s.r.o., diabetologicka a interni ambulance
Praha, Praha 1 11000
CzechiaSite Not Available
Milan Kvapil s.r.o., Diabetologicka ambulance
Praha, Praha 4 14900
CzechiaSite Not Available
ResTrial s.r.o.
Praha, Praha 8 18100
CzechiaSite Not Available
MUDr. Sabina Palova
Jilove u Prahy, Praha-západ 252 42
CzechiaSite Not Available
Milan Kvapil s.r.o., Diabetologicka ambulance Pribram
Pribram, Středočeský Kraj 26201
CzechiaSite Not Available
Endokrinologie MUDr. Rehorkova s.r.o.
Hradec Kralove, 500 12
CzechiaSite Not Available
Diahelp s.r.o
Pardubice, 530 02
CzechiaSite Not Available
MUDr. Jitka Zemanová - diabetologie a interna s.r.o.
Plzen, 326 00
CzechiaSite Not Available
Nemocnice Cesky Krumlov
Český Krumlov, 381 01
CzechiaSite Not Available
Nemocnice Cesky Krumlov, a.s.
Český Krumlov, 381 01
CzechiaActive - Recruiting
CDG Studienambulanz Hartard
München, Bayern 80809
GermanySite Not Available
Gemeinschaftspraxis Dr. med. Josef und Wilma Großkopf
Wallerfing, Bayern 94574
GermanySite Not Available
Ceda-Research
Pohlheim, Hessen 35415
GermanySite Not Available
Diabetologische Schwerpunktpraxis Marck Linn Pickel
Pohlheim, Hessen 35415
GermanySite Not Available
Diabetologische Schwerpunktpraxis Marck Linn Pickel
Pulheim, Hessen 35415
GermanySite Not Available
Institut für Diabetesforschung GmbH Münster
Münster, Nordrhein- 48145
GermanySite Not Available
InnoDiab Forschung Gmbh
Essen, Nordrhein-Westfalen 45136
GermanySite Not Available
Medizentrum Essen Borbeck
Essen, Nordrhein-Westfalen 45355
GermanySite Not Available
Universitaetsklinikum Koeln
Köln, Nordrhein-Westfalen 50937
GermanySite Not Available
University Hospital of Cologne
Köln, Nordrhein-Westfalen 50937
GermanySite Not Available
Gemeinschaftspraxis Dr. med. Ralf Denger und Dr. med. Thomas Pfitzner
Friedrichsthal, Saarland 66299
GermanySite Not Available
Practice Dr.med. Denger and Dr.med. Pfitzner
Friedrichsthal, Saarland 66299
GermanySite Not Available
AmBeNet GmbH
Leipzig, Sachsen 04107
GermanySite Not Available
Arztpraxis Christine Kosch Pirna
Pirna, Sachsen 01796
GermanySite Not Available
Private Practice - Dr. Christine Kosch
Pirna, Sachsen 01796
GermanySite Not Available
Hausarzt- und Diabetologische Schwerpunktpraxis Hohenmölsen - Weiβenfels
Hohenmölsen, Sachsen-Anhalt 06679
GermanySite Not Available
SMO.MD GmbH
Magdeburg, Sachsen-Anhalt 39120
GermanySite Not Available
Universität zu Lübeck - Institut für Endokrinologie und Diabetes
Lübeck, Schleswig-Holstein 23562
GermanySite Not Available
RED-Institut GmbH
Oldenburg, Schleswig-Holstein 23758
GermanySite Not Available
Diabetes Zentrum Dr. Tews
Gelnhausen, 63571
GermanySite Not Available
Diabetes Zentrum Wilhelmsburg
Hamburg, 21109
GermanySite Not Available
Athens Medical Center
Athens, Attikí 151 25
GreeceSite Not Available
Hippokration University Hopsital
Thessaloniki, Kentrikí Makedonía 54642
GreeceSite Not Available
Ippokrateio General Hospital of Thessaloniki
Thessaloniki, Kentrikí Makedonía 54642
GreeceSite Not Available
Euromedica General Clinic of Thessaloniki
Thessaloniki, Thessaloníki 546 45
GreeceSite Not Available
Papageorgiou General Hospital of Thessaloniki
Thessaloniki, Thessaloníki 564 29
GreeceSite Not Available
Thermi Clinic
Thessaloniki, Thessaloníki 570 01
GreeceSite Not Available
University General Hospital of Larissa
Larissa, Thessalía 41110
GreeceSite Not Available
424 Military General Training Hospital
Thessaloniki, 564 29
GreeceSite Not Available
All India Institute of Medical Sciences
Raipur, Chhattisgarh 492099
IndiaSite Not Available
Dr B. L. Kapur Memorial Hospital
New Delhi, Delhi 110005
IndiaSite Not Available
Shree Krishna Hospital
Anand, Gujarat 388325
IndiaSite Not Available
Shree Krishna Hospital
Karamsad, Gujarat 388325
IndiaSite Not Available
Medstar Speciality Hospital
Bangalore, Karnataka 560092
IndiaSite Not Available
Karnataka Institute of Medical Sciences
Hubli, Karnataka 580021
IndiaSite Not Available
TOTALL Diabetes Hormone Institute
Indore, Madhya Pradesh 452010
IndiaSite Not Available
Government Medical College, Aurangabad
Aurangabad, Maharashtra 431001
IndiaSite Not Available
BSES MG Hospital
Mumbai, Maharashtra 400058
IndiaSite Not Available
Topiwala National Medical College & B. Y. L. Nair Charitable Hospital
Mumbai, Maharashtra 400008
IndiaSite Not Available
All India Institute of Medical Sciences (AIIMS) - Nagpur
Nagpur, Maharashtra 441108
IndiaSite Not Available
Sahyadri Super Speciality Hospital
Pune, Maharashtra 411004
IndiaSite Not Available
Arthur Asirvatham Hospital
Madurai, Tamil Nadu 625020
IndiaSite Not Available
Kumudini Devi Diabetes Research Center
Hyderabad, Telangana 500082
IndiaSite Not Available
Fortis Hospital
Noida, Uttar Pradesh 201301
IndiaSite Not Available
Fortis Hospital
Delhi, 110088
IndiaSite Not Available
Wonju Severance Christian Hospital
Wonju, Kang-won-do 26426
Korea, Republic ofActive - Recruiting
Yonsei University-Wonju Severance Christian Hospital
Wonju, Kang-won-do 26426
Korea, Republic ofSite Not Available
Seoul National University Bundang Hospital
Seongnam, Kyǒnggi-do 13620
Korea, Republic ofSite Not Available
Yeungnam Univeristy Medical Center
Gyeongsan-si, Kyǒngsangbuk-do 42415
Korea, Republic ofSite Not Available
Korea University Anam Hospital
Seoul, Seoul-teukbyeolsi [Seoul] 02841
Korea, Republic ofSite Not Available
Kyung Hee University Hospital at Gangdong
Seoul, Seoul-teukbyeolsi [Seoul] 134-090
Korea, Republic ofSite Not Available
The Catholic Univ. of Korea Seoul St. Mary's Hospital
Seoul, Seoul-teukbyeolsi [Seoul] 06591
Korea, Republic ofSite Not Available
Advanced Clinical Research, LLC
Bayamón, 00959
Puerto RicoSite Not Available
Isis Clinical Research Center
Guaynabo, 00968
Puerto RicoSite Not Available
Private Practice - Dr. Paola Mansilla-Letelier
Guaynabo, 00968
Puerto RicoSite Not Available
Cahaba Research - Pelham
Pelham, Alabama 35124
United StatesSite Not Available
Novak Clinical Research - Tucson - North La Cholla Boulevard
Tucson, Arizona 85741
United StatesSite Not Available
Yuma Clinical Trials
Yuma, Arizona 85364
United StatesSite Not Available
AMCR Institute
Escondido, California 92025
United StatesSite Not Available
National Research Institute - Huntington Park
Huntington Park, California 90255
United StatesSite Not Available
Velocity Clinical Research, Huntington Park
Huntington Park, California 90255
United StatesSite Not Available
National Research Institute - Wilshire
Los Angeles, California 90057
United StatesSite Not Available
Velocity Clinical Research, Westlake
Los Angeles, California 90057
United StatesSite Not Available
Catalina Research Institute, LLC
Montclair, California 91763
United StatesSite Not Available
University Clinical Investigators, Inc.
Tustin, California 92780
United StatesSite Not Available
Encore Medical Research
Hollywood, Florida 33024
United StatesSite Not Available
East Coast Institute for Research, LLC
Jacksonville, Florida 32216
United StatesSite Not Available
South Florida Clinical Research Institute
Margate, Florida 33063
United StatesSite Not Available
Suncoast Clinical Research, Inc.
New Port Richey, Florida 34652
United StatesSite Not Available
Balanced Life Health Care Solutions/SKYCRNG
Lawrenceville, Georgia 30046
United StatesSite Not Available
Endocrine Research Solutions, Inc.
Roswell, Georgia 30076
United StatesSite Not Available
North Georgia Clinical Research
Woodstock, Georgia 30189
United StatesSite Not Available
Pacific Diabetes & Endocrine Center
Honolulu, Hawaii 96813
United StatesSite Not Available
Solaris Clinical Research
Meridian, Idaho 83646
United StatesSite Not Available
Iowa Diabetes and Endocrinology Research Center
West Des Moines, Iowa 50265
United StatesSite Not Available
MedStar Good Samaritan Hospital
Baltimore, Maryland 21239
United StatesSite Not Available
Arcturus Healthcare , PLC, Troy Internal Medicine Research Division
Troy, Michigan 48098
United StatesSite Not Available
StudyMetrix Research
Saint Peters, Missouri 63303
United StatesSite Not Available
Las Vegas Medical Research
Las Vegas, Nevada 89128
United StatesSite Not Available
Albuquerque Neuroscience Inc.
Albuquerque, New Mexico 87109
United StatesSite Not Available
IMA Clinical Research
Albuquerque, New Mexico 87109
United StatesSite Not Available
Albany Medical College, Division of Community Endocrinology
Albany, New York 12203
United StatesSite Not Available
Albany Stratton VA Medical Center
Albany, New York 12208
United StatesSite Not Available
NYC Research INC
Long Island City, New York 11106
United StatesSite Not Available
Accellacare - Raleigh
Raleigh, North Carolina 27609
United StatesSite Not Available
Summit Headlands
Portland, Oregon 97210
United StatesSite Not Available
Summit Research Network
Portland, Oregon 97210
United StatesActive - Recruiting
Alliance for Multispecialty Research, LLC
Knoxville, Tennessee 37909
United StatesSite Not Available
Dallas Diabetes Research Center
Dallas, Texas 75230
United StatesSite Not Available
Velocity Clinical Research, Dallas
Dallas, Texas 75230
United StatesSite Not Available
Epic Medical Research - DeSoto
DeSoto, Texas 75115
United StatesSite Not Available
Soma Clinical Trials
Denison, Texas 75020
United StatesSite Not Available
Biopharma Informatic, LLC
Houston, Texas 77043
United StatesSite Not Available
Epic Medical Research
Red Oak, Texas 75154
United StatesSite Not Available
Diabetes and Glandular Disease Center
San Antonio, Texas 78229
United StatesSite Not Available
VIP Trials
San Antonio, Texas 78230
United StatesSite Not Available
Charlottesville Medical Research
Charlottesville, Virginia 22911
United StatesSite Not Available
Universal Research Group
Tacoma, Washington 98405
United StatesSite Not Available
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