Functional Instability in Patients Suffering From Collagen Disease and Joint Hypermobility

Last updated: July 18, 2025
Sponsor: Istituto Ortopedico Rizzoli
Overall Status: Active - Recruiting

Phase

N/A

Condition

Lupus

Joint Injuries

Collagen Vascular Diseases

Treatment

Clinical tests and balance evaluation using the Delos Proprioceptive System

Clinical Study ID

NCT05871216
0006530
  • Ages 18-60
  • All Genders

Study Summary

A joint is considered "hypermobile" when it has a greater range of motion than normal for a given age, ethnicity or gender. Many people have asymptomatic hyperlaxity in multiple joints, a condition called Generalized Joint Hypermobility (GJH).

Conversely, hyperlaxity can be symptomatic, a condition that has been defined "Joint Hypermobility Syndrome" - JHS.

Diagnosis of JHS is commonly performed by applying the revised Brighton criteria. Based on these criteria, an individual is diagnosed with JHS with a Beighton score >/= 4/9, and arthralgia for 3 or more months in 4 or more joints (major criteria).

The dynamic body balance test (i.e. the stability test with multiple single-leg jumps) can provide information regarding the effectiveness of the feedforward and feedback mechanisms in correcting the postural deviations necessary to achieve successful performance during daily and sporting activities. Such assessment may also be useful to demonstrate deficiencies in balance, especially in young patients with increased physical activity.

The aim of this study is to examine the postural balance of individuals with JHS by performing stability tests in monopodalic and bipodalic stance with the "Delos Postural Proprioceptive System"

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients with moderate (Beighton-Horan Joint Mobility Index score from 3 to 4) orsevere (Beighton-Horan Joint Mobility Index score from 5 to 9) joints hyperlaxity atthe clinical evaluation

Exclusion

Exclusion Criteria:

  • Obesity (BMI > 25) and weight > 90 kg

  • Practice of competitive sport

  • Orthopedic (complex surgery of the spine and lower limbs), neurological (spasticity,stroke), and oncological comorbidities

  • Orthostatic / walking inability

  • Absence of joints hyperlaxity at the clinical evaluation (Beighton-Horan JointMobility Index score from 0 to 2)

Study Design

Total Participants: 30
Treatment Group(s): 1
Primary Treatment: Clinical tests and balance evaluation using the Delos Proprioceptive System
Phase:
Study Start date:
October 01, 2020
Estimated Completion Date:
March 30, 2026

Connect with a study center

  • IRCCS-Istituto Ortopedico Rizzoli

    Bologna, 40136
    Italy

    Active - Recruiting

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.