Beetroot Juice and Sleep

Last updated: September 22, 2025
Sponsor: Mayo Clinic
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

Placebo Beetroot Juice Supplement (pBRJ)

Active Beetroot Juice Supplement (aBRJ)

Clinical Study ID

NCT05864521
23-000874
  • Ages 18-80
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The purpose of this study is to investigate the effects of acute inorganic nitrate supplementation (with beetroot) on the regulation of sleep and neurovascular physiology.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • 18-35 or 65-80 years of age

Exclusion

Exclusion Criteria:

  • Coronary artery disease

  • Heart failure

  • Pregnancy

  • Diabetes

  • Sleep disorders

  • Shift workers

  • Individuals who typically go to sleep after midnight

  • Individuals who traveled across ≥2 time zones within one week of study visits

  • Individuals with a history frequent kidney stones

  • BMI ≥35.0kg/m2

  • Use of nicotine-containing products within the two years preceding study visits

  • Use of allopurinol, proton pump inhibitors, or other medications/supplements whichinterfere with the nitrate-nitrite-nitric oxide pathway or outcome measures

Study Design

Total Participants: 60
Treatment Group(s): 2
Primary Treatment: Placebo Beetroot Juice Supplement (pBRJ)
Phase:
Study Start date:
September 28, 2023
Estimated Completion Date:
June 30, 2026

Connect with a study center

  • Mayo Clinic in Rochester

    Rochester, Minnesota 55905
    United States

    Site Not Available

  • Mayo Clinic in Rochester

    Rochester 5043473, Minnesota 5037779 55905
    United States

    Active - Recruiting

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