Targeted Motor Learning to Improve Gait for Individuals With Parkinson Disease

Last updated: October 30, 2024
Sponsor: University of North Carolina, Chapel Hill
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

dTRAC

Gait training without rhythmic auditory cues

TRAC

Clinical Study ID

NCT05864157
23-0021
R21HD111833
  • Ages 50-80
  • All Genders

Study Summary

The purpose of this research study is to determine how training to step with a metronome on both a treadmill, as well as overground, will influence the way that people with Parkinson disease walk. Using metronomes is commonly used in clinics, but the investigators will be using a combination of slow and fast frequencies to alter the way that people walk. The use of a slower frequency metronome on the treadmill is intended to help participants take larger steps. The use of a faster frequency metronome while walking overground is intended to help participants take faster steps.This will take place over 12 training sessions. Each session will be about an hour. It will include some walking tests and pictures of the brain (using MRI) before and after training.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • idiopathic Parkinson's disease (Hoehn and Yahr Stage 2-3)

  • self-report the ability to walk uninterrupted for 10 minutes both overground and ona treadmill without therapist assistance

  • comfortable gait speed > 0.4 m/s and < 1.2 m/s

  • normal (or corrected to normal [i.e., hearing aid]) hearing

  • deficits in gait continuity (e.g., shuffling, shortened strides, freezing,festination, bradykinesia, etc) based on observational gait analysis

  • Movement Disorders Society - Unified Parkinson Disease Rating Scale (MDS-UPDRS-III)item 10 ≥1 and <3

  • be on stable doses of orally-administered levodopa

  • age 50-80 years old

Exclusion

Exclusion Criteria:

  • contraindications to MRI (e.g., metal implants, claustrophobia, etc)

  • cognitive deficits (Montreal Cognitive Assessment [MoCA] < 26)

  • concurrent Physical Therapy

  • have undergone deep brain stimulation surgery

  • cannot walk without therapist assistance

  • uncontrolled cardiorespiratory/metabolic disease, or other neurological disorders ororthopedic injury that may affect gait.

Study Design

Total Participants: 45
Treatment Group(s): 3
Primary Treatment: dTRAC
Phase:
Study Start date:
August 16, 2023
Estimated Completion Date:
May 03, 2026

Study Description

Some details regarding the metronome frequency are purposely omitted at this time to preserve scientific integrity. They will be included after the trial is complete

Connect with a study center

  • University of North Carolina at Chapel Hill

    Chapel Hill, North Carolina 27599
    United States

    Active - Recruiting

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