A Phase 1 Study of ZL-1218 in Subjects With Advanced Solid Tumors

Inclusion Criteria:

• Adult men and women ≥ 18 years of age. If 18 years is not the age of majority, thenadult men and women ≥ age of majority per local regulation.

• Eastern Cooperative Oncology Group (ECOG) performance status of 0-1.

• Life expectancy > 12 weeks.

• Subjects must have histologically confirmed and documented diagnosis of locallyadvanced unresectable or metastatic advanced solid tumor that is refractory tostandard treatment, or intolerant to standard treatment, or for which no standardtreatment exists.Subjects must have at least one target lesion as defined by RECISTv1.1 on CT, PET/CT, or MRI scan.

• Subjects must have a site of disease which is not previously irradiated and is safeand amenable to biopsy per the treating institution's guidelines. Subjects must bewilling to undergo a tumor biopsy at screening and on treatment, per the protocolguidelines.

• Subjects must have a site of disease which is not previously irradiated and is safeand amenable to biopsy per the treating institution's guidelines. Subjects must bewilling to undergo a tumor biopsy at screening and on treatment, per the protocolguidelines.

Exclusion Criteria:

• Symptomatic or uncontrolled brain metastasis requiring concurrent treatment,inclusive of but not limited to surgery, radiation, and/or corticosteroids.

• Prior exposure to CCR8 inhibitor (anti-CCR8 antibody) or hypersensitivity to anyingredient of the study drug.

• Out of range value within 10 days prior to the first dose of study treatment.

• Subjects have received a live or live-attenuated vaccine within 30 days of plannedstart of study therapy.

• Subjects with known history of, or any evidence of active, non-infectiouspneumonitis.

• Impaired cardiac function or clinically significant cardiac disease within the last 3 months before administration of the first dose of the study drug.

• Treatment with any systemic anti-cancer treatment (including investigationalproducts) within 4 weeks before first dose of study drug.

• Non-palliative radiotherapy within 2 weeks prior to first dose of study drug or havehad history of radiation pneumonitis.

• Major surgery within 4 weeks of the first dose of study drug.

• Infections requiring systemic antibiotic therapy.

• Any medical conditions that would, in the investigator's judgement, prevent thesubject's participation in the clinical study due to safety concerns, compliancewith the study procedures, or interpretation of the study results.