Psychosis TMS Study

Last updated: March 20, 2025
Sponsor: Massachusetts General Hospital
Overall Status: Active - Not Recruiting

Phase

N/A

Condition

Schizotypal Personality Disorder (Spd)

Schizophrenia And Schizoaffective Disorders (Pediatric)

Psychosis

Treatment

Placebo TMS

Active TMS

Clinical Study ID

NCT05857137
2018P000014
  • Ages 18-35
  • All Genders

Study Summary

The main goal of this study is to investigate the neural mechanisms of working memory function in patients with early psychosis using Transcranial Magnetic Stimulation (TMS) in conjunction with functional MRI. TMS is a noninvasive method used to modulate brain activity via changing magnetic fields applied over the surface of the scalp.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Diagnosis of psychosis, psychosis not otherwise specified, schizophrenia,schizoaffective disorder, delusional disorder, bipolar disorder with psychosis, andschizophreniform disorder within first ten years of onset of psychotic symptoms.

  • Ability to provide informed consent

Exclusion

Exclusion Criteria:

  • TMS incompatibility including metallic implants in head and neck, cardiacpacemakers, history of seizures, pregnancy.

  • MRI-incompatibility including implanted aneurism clips, cardiac pacemakers, metalimplants, intrauterine devices, tattoos containing metal ink, pregnancy, andclaustrophobia

  • Severe substance abuse within 3 months (nicotine allowed)

  • Unstable medical or neurologic illness that would preclude participation in studyprocedures

Study Design

Total Participants: 20
Treatment Group(s): 2
Primary Treatment: Placebo TMS
Phase:
Study Start date:
April 04, 2023
Estimated Completion Date:
April 30, 2025

Connect with a study center

  • Martinos Center for Biomedical Imaging

    Charlestown, Massachusetts 02129
    United States

    Site Not Available

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